TB-Profiler result

Run: ERR11081010
Summary

Run ID: ERR11081010

Sample name:

Date: 08-04-2023 02:19:07

Number of reads: 1680584

Percentage reads mapped: 99.56

Strain: lineage4.1.2

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
ethR 4327876 p.Phe110Leu missense_variant 1.0 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6077 p.Gly280Arg missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800889 c.81C>A synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472580 n.735C>G non_coding_transcript_exon_variant 1.0
rrl 1474039 n.382A>G non_coding_transcript_exon_variant 0.15
fabG1 1673346 c.-94C>G upstream_gene_variant 0.16
fabG1 1673349 c.-91G>C upstream_gene_variant 0.15
fabG1 1673357 c.-83G>A upstream_gene_variant 0.26
fabG1 1673359 c.-81T>C upstream_gene_variant 0.27
fabG1 1673361 c.-79C>G upstream_gene_variant 0.27
fabG1 1673380 c.-60C>G upstream_gene_variant 0.4
rpsA 1834934 p.Ala465Thr missense_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102075 p.Met323Lys missense_variant 0.12
katG 2153970 p.Asp714Glu missense_variant 0.18
PPE35 2168303 c.2310G>T synonymous_variant 1.0
PPE35 2169776 p.Phe279Leu missense_variant 1.0
PPE35 2170035 p.Val193Ala missense_variant 0.2
PPE35 2170048 p.Leu189Val missense_variant 0.44
PPE35 2170053 p.Thr187Ser missense_variant 0.4
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2519003 p.Leu297Met missense_variant 0.12
Rv2752c 3066004 p.Asp63Gly missense_variant 1.0
thyX 3067345 p.Ser201Cys missense_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449172 c.669C>T synonymous_variant 0.25
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642240 p.Gly236Arg missense_variant 0.14
alr 3840263 c.1158C>T synonymous_variant 1.0
embC 4240667 p.Ser269Pro missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244868 p.Ser546Cys missense_variant 0.12
embB 4246548 p.Pro12Gln missense_variant 0.17
embB 4246555 c.42G>C synonymous_variant 0.2
embB 4246556 p.Ala15Pro missense_variant 0.2
embB 4249549 p.Phe1012Leu missense_variant 0.13
aftB 4267207 p.Val544Met missense_variant 0.12
aftB 4268728 p.Thr37Ala missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0