TB-Profiler result

Run: ERR176756

Summary

Run ID: ERR176756

Sample name:

Date: 24-01-2024 12:25:33

Number of reads: 3190709

Percentage reads mapped: 68.19

Strain: lineage4.9.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
lineage4.9.1 Euro-American (H37Rv-like) T1 None 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8978 c.1677C>T synonymous_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.43
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.45
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.48
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.45
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.45
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.43
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.35
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.38
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.37
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.33
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.29
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.58
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.61
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.65
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.65
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.76
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.83
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.79
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.72
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.61
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223145 p.Arg7Lys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 1.0
pncA 2289448 c.-207G>A upstream_gene_variant 1.0
Rv2752c 3067191 c.-1000G>A upstream_gene_variant 1.0
fbiD 3339385 p.Asp90Asn missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0