TB-Profiler result

Run: ERR221550
Summary

Run ID: ERR221550

Sample name:

Date: 31-03-2023 16:16:08

Number of reads: 2173681

Percentage reads mapped: 79.29

Strain: lineage4.3.4.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 0.98
lineage4.3.4 Euro-American (LAM) LAM RD174 0.98
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 0.98
lineage4.3.4.2.1 Euro-American (LAM) LAM11 RD174 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6140 p.Val301Leu missense_variant 0.96
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764995 c.1626C>G synonymous_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.28
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.31
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.31
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.31
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.29
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.26
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.26
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.31
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.27
rrs 1472733 n.888G>C non_coding_transcript_exon_variant 0.11
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.15
rrs 1472742 n.897C>G non_coding_transcript_exon_variant 0.11
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.11
rrs 1473147 n.1302G>C non_coding_transcript_exon_variant 0.1
rrs 1473161 n.1316A>C non_coding_transcript_exon_variant 0.14
rrs 1473164 n.1319C>G non_coding_transcript_exon_variant 0.12
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.12
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.12
rrs 1473179 n.1334C>T non_coding_transcript_exon_variant 0.12
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.12
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.14
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.29
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.29
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.24
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.29
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.33
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.27
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.27
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.24
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.15
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.21
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.27
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.27
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.27
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.27
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.27
rrl 1475843 n.2186G>A non_coding_transcript_exon_variant 0.21
rrl 1475849 n.2192G>A non_coding_transcript_exon_variant 0.22
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.25
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.29
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.16
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.23
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.36
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.39
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.4
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.43
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.44
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.59
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.59
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.6
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.36
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.32
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.14
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714926 p.Thr136Ser missense_variant 0.97
thyA 3073868 p.Thr202Ala missense_variant 0.97
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339153 p.Leu12Phe missense_variant 0.27
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0
alr 3840719 c.702A>G synonymous_variant 0.95
clpC1 4038287 c.2418C>T synonymous_variant 0.98
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 0.94