TB-Profiler result

Run: ERR233367
Summary

Run ID: ERR233367

Sample name:

Date: 21-10-2023 03:12:06

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage6.2.2;lineage4

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.09
lineage6 West-Africa 2 AFRI_1 RD702 0.92
lineage6.2 West-Africa 2 AFRI_1 RD702 0.91
lineage6.2.2 West-Africa 2 AFRI_1 RD702 0.94
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5072 c.-168G>T upstream_gene_variant 0.95
gyrB 6446 p.Ala403Ser missense_variant 0.94
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8493 p.Leu398Phe missense_variant 0.91
gyrA 9143 c.1842T>C synonymous_variant 0.93
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491668 p.Lys296Glu missense_variant 0.92
fgd1 491742 c.960T>C synonymous_variant 0.93
rpoB 760115 c.309C>T synonymous_variant 0.14
rpoB 760969 p.Ser388Leu missense_variant 0.95
rpoB 761723 p.Glu639Asp missense_variant 0.89
rpoB 762041 c.2235C>T synonymous_variant 0.9
rpoC 763031 c.-339T>C upstream_gene_variant 0.91
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.96
mmpL5 777407 p.Ile358Met missense_variant 0.83
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 0.82
Rv1258c 1406685 p.Val219Ala missense_variant 0.98
embR 1416633 p.Leu239Val missense_variant 0.85
atpE 1461251 c.207G>T synonymous_variant 0.9
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674434 p.Val78Ala missense_variant 0.94
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.92
katG 2155503 c.609C>T synonymous_variant 0.83
PPE35 2167926 p.Leu896Ser missense_variant 0.9
PPE35 2169269 c.1340_1344delGCCAAinsT frameshift_variant&missense_variant 0.82
Rv1979c 2222308 p.Asp286Gly missense_variant 0.88
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 0.93
ald 3086728 c.-92C>T upstream_gene_variant 0.83
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 0.89
whiB7 3568605 c.75C>T synonymous_variant 0.9
Rv3236c 3612800 p.Val106Ala missense_variant 0.89
alr 3840559 p.Arg288Ser missense_variant 0.9
alr 3840618 p.Asp268Gly missense_variant 0.89
embC 4241843 p.Leu661Ile missense_variant 0.94
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243541 c.309C>T synonymous_variant 0.77
embA 4243682 c.450T>G synonymous_variant 0.94
embA 4244220 c.988C>T synonymous_variant 1.0
embA 4244379 p.Pro383Ser missense_variant 0.94
embB 4246864 c.351C>T synonymous_variant 0.92
embB 4247646 p.Glu378Ala missense_variant 0.89
aftB 4269351 c.-515C>T upstream_gene_variant 0.94
ubiA 4269387 p.Glu149Asp missense_variant 0.95
aftB 4269606 c.-770T>C upstream_gene_variant 0.98
ethA 4326465 p.Ile337Val missense_variant 0.9
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.88