TB-Profiler result

Run: ERR2497906
Summary

Run ID: ERR2497906

Sample name:

Date: 2024-04-16T02:11:13.804476

Number of reads: 618039

Percentage reads mapped: 99.98

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ile491Phe Assoc w R
isoniazid ahpC c.-81C>T Uncertain significance Mutation from literature
c.-48G>A Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761277 p.Ile491Phe missense_variant 0.45 rifampicin Assoc w R
ahpC 2726112 c.-81C>T upstream_gene_variant 0.31 isoniazid Uncertain significance Mutation from literature
ahpC 2726145 c.-48G>A upstream_gene_variant 0.71 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
katG 2155272 c.840G>C synonymous_variant 0.68 isoniazid Not assoc w R - Interim