TB-Profiler result

Run: ERR3287446

Summary

Run ID: ERR3287446

Sample name:

Date: 20-10-2023 05:48:45

Number of reads: 3921598

Percentage reads mapped: 99.62

Strain: lineage4.1.1.3

Drug-resistance: HR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid R katG p.Ser315Thr (0.91), ahpC p.Asp73His (0.96)
Ethambutol R embB p.Gly406Ala (0.95)
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.96
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 0.97
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 0.91 isoniazid
ahpC 2726409 p.Asp73His missense_variant 0.96 isoniazid
embB 4247730 p.Gly406Ala missense_variant 0.95 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 0.95
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302954 c.24G>A synonymous_variant 0.96
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154678 c.1434G>C synonymous_variant 0.95
PPE35 2169405 p.Asn403Ser missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449437 c.936_942delCGCGGCG frameshift_variant 0.95
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.96
embB 4249408 c.2895G>A synonymous_variant 0.97
embB 4249678 c.3165C>A synonymous_variant 0.95
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407934 p.Leu90Arg missense_variant 0.97