TB-Profiler result

Run: ERR4796331
Summary

Run ID: ERR4796331

Sample name:

Date: 01-04-2023 06:47:52

Number of reads: 3304962

Percentage reads mapped: 99.7

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
gid 4408087 c.115delC frameshift_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5078 c.-162_-161insG upstream_gene_variant 1.0
gyrB 5317 c.78C>A synonymous_variant 1.0
gyrB 6852 p.Gln538Arg missense_variant 0.99
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9746 p.Ile815Met missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.29
mshA 576113 p.Arg256Gly missense_variant 0.24
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918584 c.645A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.16
fbiD 3339734 p.Ala206Gly missense_variant 0.45
whiB7 3568427 p.Arg85Cys missense_variant 0.18
rpoA 3878637 c.-130G>C upstream_gene_variant 0.3
embB 4246548 p.Pro12Gln missense_variant 0.35
embB 4246555 c.42G>C synonymous_variant 0.35
embB 4246556 p.Ala15Pro missense_variant 0.32
embB 4246563 p.Leu17Trp missense_variant 0.26
embB 4246567 c.54G>T synonymous_variant 0.36
embB 4249423 p.Asp970Glu missense_variant 1.0
aftB 4268619 p.Val73Gly missense_variant 0.23
whiB6 4338595 c.-75delG upstream_gene_variant 1.0