TB-Profiler result

Run: ERR4814572
Summary

Run ID: ERR4814572

Sample name:

Date: 01-04-2023 13:22:27

Number of reads: 3474958

Percentage reads mapped: 90.0

Strain: lineage4.3.3

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.66 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.28
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.5
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.45
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.74
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.76
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.83
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.81
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.81
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.82
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.83
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.84
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.68
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.44
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.42
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.42
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.42
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.38
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.33
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.32
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.29
rrs 1472687 n.842_843insC non_coding_transcript_exon_variant 0.29
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.27
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.45
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.5
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.54
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.66
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.66
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.66
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.57
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.54
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.24
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.15
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.18
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.25
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.44
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.44
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.5
rrl 1474275 n.618T>C non_coding_transcript_exon_variant 0.5
rrl 1476050 n.2393G>C non_coding_transcript_exon_variant 0.11
rpsA 1834836 p.Met432Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156196 c.-85C>T upstream_gene_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
folC 2746340 p.Ala420Val missense_variant 1.0
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0