TB-Profiler result

Run: ERR4815784
Summary

Run ID: ERR4815784

Sample name:

Date: 20-10-2023 07:55:28

Number of reads: 3161270

Percentage reads mapped: 95.4

Strain: lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin R rrs n.888G>A (0.49)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.49 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.41
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.45
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.45
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.46
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.58
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.52
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.57
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.69
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.68
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.8
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.85
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.9
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.9
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.93
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.93
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.93
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.95
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.9
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.88
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.6
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.45
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.47
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.42
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.47
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.52
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.58
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.5
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.71
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.56
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.54
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.71
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.63
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.59
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.58
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.54
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.39
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.35
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.35
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.35
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.32
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.32
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.32
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.3
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.35
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.49
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.3
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.29
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.43
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.33
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.33
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.35
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0
rrl 1474637 n.980C>G non_coding_transcript_exon_variant 1.0
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 1.0
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 1.0
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.69
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.85
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.86
rrl 1476164 n.2507A>T non_coding_transcript_exon_variant 0.47
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.5
rrl 1476194 n.2537A>T non_coding_transcript_exon_variant 0.47
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.47
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.44
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.44
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.43
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.43
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.55
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.62
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.73
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 0.99
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714526 c.805_806delAC frameshift_variant 1.0
Rv2752c 3065711 p.Gly161Ser missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4247161 c.648G>C synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0