TB-Profiler result

Run: ERR4816057
Summary

Run ID: ERR4816057

Sample name:

Date: 01-04-2023 14:12:52

Number of reads: 753345

Percentage reads mapped: 99.48

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6332 p.Pro365Thr missense_variant 0.4
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7874 c.573G>A synonymous_variant 0.2
gyrA 7948 p.Leu216Arg missense_variant 0.29
gyrA 9304 p.Gly668Asp missense_variant 0.94
fgd1 491721 c.939A>G synonymous_variant 0.15
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
mshA 576074 p.Asp243Asn missense_variant 0.2
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 760018 p.Arg71Gln missense_variant 0.2
rpoC 762848 c.-522G>A upstream_gene_variant 0.17
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764202 p.Arg278Pro missense_variant 0.2
rpoC 765340 c.1971G>A synonymous_variant 0.33
rpoC 766645 p.Glu1092Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 777156 c.1324delC frameshift_variant 0.13
mmpL5 777896 p.Asp195Glu missense_variant 0.2
mmpL5 778330 p.Pro51Ser missense_variant 0.1
mmpS5 778588 p.Gln106His missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781561 c.2T>C start_lost 0.11
rplC 801336 c.528C>G synonymous_variant 0.15
fbiC 1303292 p.Thr121Met missense_variant 0.14
fbiC 1303496 p.Pro189Leu missense_variant 0.2
fbiC 1305409 p.Ala827Thr missense_variant 0.11
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167965 p.Ala883Gly missense_variant 0.11
PPE35 2167967 c.2646A>C synonymous_variant 0.12
Rv1979c 2222958 c.207A>G synonymous_variant 0.1
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518395 p.Leu94Pro missense_variant 0.12
kasA 2518641 p.Glu176Val missense_variant 0.18
eis 2714641 p.Thr231Ser missense_variant 0.11
ribD 2986719 c.-120G>C upstream_gene_variant 0.15
ribD 2987120 c.282C>G synonymous_variant 0.18
thyX 3067493 c.453A>G synonymous_variant 0.14
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087317 c.498C>A synonymous_variant 0.4
fprA 3473881 c.-125delA upstream_gene_variant 0.13
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568864 c.-185G>A upstream_gene_variant 0.15
Rv3236c 3612120 p.Arg333Trp missense_variant 0.18
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
Rv3236c 3612925 c.192C>A synonymous_variant 0.11
fbiA 3641058 p.Trp172Cys missense_variant 0.11
fbiB 3641439 c.-96C>T upstream_gene_variant 0.17
fbiB 3642038 c.504C>T synonymous_variant 0.18
rpoA 3878171 p.Pro113Thr missense_variant 0.15
clpC1 4038176 c.2529G>A synonymous_variant 0.17
clpC1 4039666 p.Val347Met missense_variant 0.11
embC 4240079 p.Pro73Thr missense_variant 0.11
embC 4241094 p.Cys411Phe missense_variant 0.2
embC 4242359 p.Asn833Asp missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4243140 p.Arg1093His missense_variant 0.22
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4244136 p.Ala302Ser missense_variant 0.17
embB 4246544 p.Thr11Pro missense_variant 0.17
embB 4246548 p.Pro12Gln missense_variant 0.18
embB 4246555 c.42G>C synonymous_variant 0.22
embB 4246556 p.Ala15Pro missense_variant 0.22
embB 4246563 p.Leu17Trp missense_variant 0.22
embB 4246567 c.54G>T synonymous_variant 0.22
embB 4249346 p.Ala945Thr missense_variant 0.13
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268821 c.16T>C synonymous_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407547 p.Ala219Val missense_variant 0.17
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0