TB-Profiler result

Run: ERR4818436
Summary

Run ID: ERR4818436

Sample name:

Date: 01-04-2023 15:33:27

Number of reads: 2579517

Percentage reads mapped: 96.58

Strain: lineage4.8

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.38 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.2 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.19
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.13
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.15
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.18
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.18
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.18
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.29
rrs 1472252 n.407G>C non_coding_transcript_exon_variant 0.22
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.22
rrs 1472256 n.411T>A non_coding_transcript_exon_variant 0.4
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.5
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.86
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.86
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.8
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.82
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.77
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.79
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.14
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.14
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.6
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.13
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.8
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.12
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.12
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.64
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.25
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.73
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.75
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.75
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.17
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.56
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.33
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.37
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.17
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.19
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.61
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.39
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.26
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.68
rrs 1472785 n.940G>T non_coding_transcript_exon_variant 0.21
rrs 1472786 n.941C>G non_coding_transcript_exon_variant 0.21
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.46
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.33
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.22
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.22
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.22
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.15
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.17
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.33
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.3
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.3
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.2
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.3
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.3
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.3
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.18
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.31
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.15
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.36
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.4
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.33
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.3
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.27
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.5
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.5
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.5
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.5
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.5
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.33
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.13
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.12
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.18
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.14
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.11
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.11
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.11
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.11
inhA 1674408 c.207G>A synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249354 c.2841G>C synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338598 c.-77G>C upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0