TB-Profiler result

Run: ERR4820989
Summary

Run ID: ERR4820989

Sample name:

Date: 01-04-2023 17:00:02

Number of reads: 706348

Percentage reads mapped: 99.67

Strain:

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 761671 p.Thr622Ile missense_variant 0.18
rpoB 762373 p.Pro856Leu missense_variant 0.15
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoB 762611 p.His935Gln missense_variant 0.12
rpoC 762794 c.-576C>T upstream_gene_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764111 p.Tyr248His missense_variant 0.12
rpoC 764413 c.1044C>A synonymous_variant 0.14
rpoC 764875 c.1506C>T synonymous_variant 0.17
rpoC 765540 p.Ala724Asp missense_variant 0.11
rpoC 767133 p.Gly1255Asp missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776397 p.Val695Gly missense_variant 0.4
mmpL5 777615 p.Arg289Leu missense_variant 0.12
mmpL5 778435 c.45delC frameshift_variant 0.13
mmpR5 779443 p.Asp152Asn missense_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303155 c.225G>A synonymous_variant 0.12
fbiC 1303594 c.664C>T synonymous_variant 0.15
Rv1258c 1407386 c.-46C>G upstream_gene_variant 0.13
embR 1417064 p.Ala95Val missense_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1833659 p.Glu40Lys missense_variant 0.3
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102860 c.183G>T synonymous_variant 0.29
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2156051 p.Pro21Thr missense_variant 0.18
katG 2156055 c.57C>A synonymous_variant 0.18
katG 2156445 c.-334G>A upstream_gene_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518113 c.-2A>T upstream_gene_variant 0.4
eis 2715432 c.-100C>T upstream_gene_variant 1.0
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
folC 2746873 p.Met242Ile missense_variant 0.12
folC 2747645 c.-49_-48delTG upstream_gene_variant 0.13
thyA 3074245 p.Gly76Val missense_variant 0.22
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087324 p.Ala169Ser missense_variant 0.14
Rv3083 3449432 p.Ala310Val missense_variant 0.17
Rv3083 3449882 p.Trp460Leu missense_variant 0.13
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475228 p.Asp408Asn missense_variant 0.12
alr 3841405 p.Glu6* stop_gained 0.11
panD 4044297 c.-16C>A upstream_gene_variant 0.13
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245458 p.Glu742Asp missense_variant 0.12
embB 4249631 p.Thr1040Ala missense_variant 0.1
aftB 4267417 p.Pro474Thr missense_variant 0.17
aftB 4267537 c.1300C>A synonymous_variant 0.15
ethA 4327281 p.Arg65Gly missense_variant 0.2
ethA 4327340 p.Trp45Ser missense_variant 1.0
ethA 4327774 c.-301G>A upstream_gene_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408070 p.Trp45Arg missense_variant 1.0
gid 4408206 c.-4C>T upstream_gene_variant 0.12