TB-Profiler result

Run: ERR4822235
Summary

Run ID: ERR4822235

Sample name:

Date: 01-04-2023 17:42:54

Number of reads: 1135944

Percentage reads mapped: 99.46

Strain: lineage2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 0.96
mshA 576488 p.Val381Gln missense_variant 0.18
ccsA 620014 p.Arg42Ser missense_variant 0.25
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473159 n.1314C>A non_coding_transcript_exon_variant 0.12
rrl 1473889 n.232G>A non_coding_transcript_exon_variant 0.11
inhA 1673643 c.-559C>T upstream_gene_variant 0.13
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167929 p.Ser895Leu missense_variant 0.13
PPE35 2170355 c.258G>A synonymous_variant 0.22
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518863 p.Thr250Lys missense_variant 0.17
eis 2714918 p.Glu139Gln missense_variant 0.12
ald 3086747 c.-73A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339366 c.249G>A synonymous_variant 0.15
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568408 p.Val91Asp missense_variant 0.14
Rv3236c 3612378 p.Val247Leu missense_variant 0.14
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
rpoA 3878531 c.-24A>G upstream_gene_variant 0.33
clpC1 4039638 p.Ile356Thr missense_variant 0.32
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243553 c.321C>A synonymous_variant 0.2
embA 4244805 p.Leu525Met missense_variant 0.12
embB 4247066 p.Ile185Val missense_variant 0.18
embB 4247915 p.Arg468Gly missense_variant 0.15
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0
gid 4408334 c.-132G>T upstream_gene_variant 0.11
gid 4408472 c.-270C>T upstream_gene_variant 0.17