TB-Profiler result

Run: ERR4831739
Summary

Run ID: ERR4831739

Sample name:

Date: 01-04-2023 21:05:29

Number of reads: 819079

Percentage reads mapped: 93.95

Strain: lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.97
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.95
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761161 p.Leu452Pro missense_variant 0.2 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.92 streptomycin
inhA 1674048 c.-154G>A upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2154227 c.1884delA frameshift_variant 0.33 isoniazid
katG 2155169 p.Ser315Gly missense_variant 1.0 isoniazid
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
embB 4247730 p.Gly406Asp missense_variant 0.17 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6917 p.His560Asn missense_variant 0.18
gyrB 6946 p.Tyr569* stop_gained 0.13
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7750 p.Val150Ala missense_variant 0.12
gyrA 8852 c.1551T>C synonymous_variant 0.11
gyrA 8858 c.1557T>C synonymous_variant 0.19
gyrA 8870 c.1569G>C synonymous_variant 0.17
gyrA 8873 c.1572A>G synonymous_variant 0.17
gyrA 8897 c.1596T>C synonymous_variant 0.12
gyrA 8903 c.1602T>C synonymous_variant 0.12
gyrA 8915 c.1614A>G synonymous_variant 0.11
gyrA 8957 c.1656C>T synonymous_variant 0.13
gyrA 8967 p.Ala556Lys missense_variant 0.14
gyrA 9026 c.1725G>C synonymous_variant 0.12
gyrA 9029 c.1728T>C synonymous_variant 0.12
gyrA 9035 c.1734G>C synonymous_variant 0.11
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490835 p.Arg18Leu missense_variant 0.22
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575575 c.228G>T synonymous_variant 0.17
mshA 575850 p.Arg168His missense_variant 0.25
mshA 575894 p.Val183Met missense_variant 0.15
mshA 576045 p.Ala233Glu missense_variant 0.15
mshA 576077 p.Leu244Met missense_variant 0.18
mshA 576114 p.Arg256Leu missense_variant 0.17
mshA 576755 p.Arg470Ser missense_variant 0.29
ccsA 619738 c.-153T>C upstream_gene_variant 0.25
ccsA 619944 p.Phe18Leu missense_variant 0.14
ccsA 619973 c.94_96delCTG conservative_inframe_deletion 0.33
ccsA 619992 c.102C>T synonymous_variant 0.2
ccsA 619993 p.Glu35Lys missense_variant 0.2
ccsA 620183 p.Arg98Leu missense_variant 0.15
ccsA 620388 c.498A>C synonymous_variant 0.13
ccsA 620397 c.507C>G synonymous_variant 0.13
ccsA 620412 c.522T>C synonymous_variant 0.17
ccsA 620415 c.525T>C synonymous_variant 0.17
ccsA 620421 c.531G>C synonymous_variant 0.17
ccsA 620430 c.540C>T synonymous_variant 0.14
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 759615 c.-192A>C upstream_gene_variant 0.25
rpoB 760415 c.609C>A synonymous_variant 0.2
rpoB 760460 c.654G>C synonymous_variant 0.17
rpoB 760475 c.669A>G synonymous_variant 0.2
rpoB 760481 c.675G>C synonymous_variant 0.2
rpoB 760484 c.678A>G synonymous_variant 0.22
rpoB 760749 p.Gly315Trp missense_variant 0.14
rpoB 761184 p.Glu460* stop_gained 0.14
rpoB 761343 p.Val513Leu missense_variant 0.13
rpoB 761405 p.His533Gln missense_variant 0.22
rpoB 762158 c.2352G>C synonymous_variant 0.12
rpoB 762167 c.2361T>C synonymous_variant 0.11
rpoB 762176 c.2370T>C synonymous_variant 0.12
rpoB 762185 c.2379G>C synonymous_variant 0.12
rpoB 762194 c.2388G>C synonymous_variant 0.13
rpoB 762329 c.2523G>C synonymous_variant 0.11
rpoB 762362 p.Glu852Asp missense_variant 0.11
rpoB 762369 c.2563T>C synonymous_variant 0.11
rpoC 762383 c.-987C>G upstream_gene_variant 0.11
rpoC 762392 c.-978G>C upstream_gene_variant 0.24
rpoC 762395 c.-975G>T upstream_gene_variant 0.24
rpoC 762398 c.-972T>C upstream_gene_variant 0.25
rpoC 762404 c.-966T>C upstream_gene_variant 0.25
rpoC 762410 c.-960T>G upstream_gene_variant 0.31
rpoC 762416 c.-954A>G upstream_gene_variant 0.27
rpoC 762449 c.-921C>A upstream_gene_variant 0.14
rpoC 762452 c.-918G>C upstream_gene_variant 0.14
rpoC 762470 c.-900G>C upstream_gene_variant 0.14
rpoC 762485 c.-885G>A upstream_gene_variant 0.14
rpoC 762488 c.-882G>C upstream_gene_variant 0.14
rpoC 762491 c.-879T>C upstream_gene_variant 0.14
rpoC 762509 c.-861T>G upstream_gene_variant 0.25
rpoB 762510 p.Ala902Pro missense_variant 0.25
rpoC 762515 c.-855C>T upstream_gene_variant 0.25
rpoB 762633 p.Ala943Ser missense_variant 0.33
rpoB 762660 p.Arg952Trp missense_variant 0.2
rpoC 762761 c.-609C>T upstream_gene_variant 0.13
rpoB 762852 p.Pro1016Thr missense_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoB 763102 p.Ala1099Glu missense_variant 0.13
rpoC 763380 p.Val4Ala missense_variant 0.12
rpoC 763981 p.Glu204Asp missense_variant 0.17
rpoC 764546 p.Gly393Trp missense_variant 0.17
rpoC 764611 c.1242G>T synonymous_variant 0.19
rpoC 764626 c.1257C>T synonymous_variant 0.19
rpoC 764632 c.1263T>C synonymous_variant 0.17
rpoC 764650 c.1281G>T synonymous_variant 0.24
rpoC 764668 c.1299C>T synonymous_variant 0.29
rpoC 764692 c.1323C>T synonymous_variant 0.22
rpoC 764713 c.1344G>T synonymous_variant 0.2
rpoC 764716 c.1347G>C synonymous_variant 0.2
rpoC 764746 c.1377G>T synonymous_variant 0.14
rpoC 764752 c.1383G>C synonymous_variant 0.13
rpoC 764758 c.1389C>G synonymous_variant 0.12
rpoC 764764 c.1395T>C synonymous_variant 0.12
rpoC 764791 c.1422C>G synonymous_variant 0.13
rpoC 764803 c.1434C>T synonymous_variant 0.12
rpoC 764810 p.Pro481Ala missense_variant 0.11
rpoC 764815 c.1446A>G synonymous_variant 0.11
rpoC 765244 c.1875T>G synonymous_variant 0.14
rpoC 765285 p.Gln639Pro missense_variant 0.12
rpoC 765295 c.1926G>A synonymous_variant 0.17
rpoC 765343 c.1974G>A synonymous_variant 0.14
rpoC 765352 c.1983G>C synonymous_variant 0.17
rpoC 765356 p.Met663Val missense_variant 0.17
rpoC 765370 c.2001G>C synonymous_variant 0.18
rpoC 765379 c.2010G>C synonymous_variant 0.33
rpoC 765382 c.2013G>T synonymous_variant 0.25
rpoC 765383 p.Met672Leu missense_variant 0.25
rpoC 765398 c.2030_2031delTG frameshift_variant 0.18
rpoC 765403 c.2034G>C synonymous_variant 0.18
rpoC 765405 p.Leu679His missense_variant 0.18
rpoC 765409 c.2040T>G synonymous_variant 0.15
rpoC 765421 c.2052C>G synonymous_variant 0.15
rpoC 766042 c.2673C>T synonymous_variant 0.4
rpoC 766668 c.3301_3309delGATGGCGAC conservative_inframe_deletion 0.13
rpoC 766724 p.His1119Asn missense_variant 0.14
rpoC 766942 c.3573C>T synonymous_variant 0.22
rpoC 766945 c.3576A>C synonymous_variant 0.22
rpoC 766963 c.3594T>C synonymous_variant 0.33
rpoC 766983 p.Pro1205Gln missense_variant 0.2
rpoC 766996 c.3627C>T synonymous_variant 0.22
rpoC 767002 c.3633G>C synonymous_variant 0.22
rpoC 767008 c.3639G>A synonymous_variant 0.25
rpoC 767023 c.3654C>T synonymous_variant 0.22
rpoC 767044 c.3675G>C synonymous_variant 0.25
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775835 c.2646C>A synonymous_variant 0.2
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776639 c.1842C>T synonymous_variant 0.17
mmpL5 776747 p.Phe578Leu missense_variant 0.13
mmpL5 777655 p.Asp276Tyr missense_variant 0.13
mmpL5 778282 p.Asp67Tyr missense_variant 0.15
mmpL5 779172 c.-692C>T upstream_gene_variant 0.25
mmpL5 779436 c.-956G>A upstream_gene_variant 0.15
mmpS5 779615 c.-710C>G upstream_gene_variant 0.94
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781684 p.Pro42Gln missense_variant 0.17
rpsL 781762 p.Pro68His missense_variant 0.12
rpsL 781897 p.Ala113Glu missense_variant 0.15
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.13
rplC 800715 c.-94A>C upstream_gene_variant 0.12
rplC 800723 c.-86C>G upstream_gene_variant 0.13
rplC 800735 c.-74C>G upstream_gene_variant 0.13
fbiC 1303207 p.Pro93Ser missense_variant 0.18
fbiC 1303216 c.286C>A synonymous_variant 0.15
fbiC 1303417 p.Gly163Cys missense_variant 0.17
fbiC 1303711 p.Val261Ile missense_variant 0.12
fbiC 1304335 p.Ala469Ser missense_variant 0.2
fbiC 1304592 p.Phe554Leu missense_variant 0.12
fbiC 1304623 p.Cys565Gly missense_variant 0.13
fbiC 1304640 c.1710A>C synonymous_variant 0.11
fbiC 1304646 c.1716T>C synonymous_variant 0.11
fbiC 1304676 c.1746A>C synonymous_variant 0.1
fbiC 1304819 p.Val630Ala missense_variant 0.11
fbiC 1304938 p.Glu670* stop_gained 0.25
fbiC 1304985 c.2055G>T synonymous_variant 0.2
fbiC 1305407 p.Ser826Leu missense_variant 0.33
Rv1258c 1406292 p.Gly350Val missense_variant 0.17
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1407227 p.Glu38Asp missense_variant 0.22
embR 1416759 p.Leu197Met missense_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471670 n.-176G>T upstream_gene_variant 0.13
rrs 1471678 n.-168A>G upstream_gene_variant 0.12
rrs 1472111 n.266C>A non_coding_transcript_exon_variant 0.17
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.12
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.13
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.11
rrl 1474585 n.928G>T non_coding_transcript_exon_variant 0.15
rrl 1474593 n.936T>C non_coding_transcript_exon_variant 0.14
rrl 1474622 n.965G>T non_coding_transcript_exon_variant 0.14
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.14
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.14
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.14
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.14
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.14
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.14
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.14
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.15
rrl 1475009 n.1352G>T non_coding_transcript_exon_variant 0.13
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.14
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.2
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.2
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.2
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.2
rrl 1475766 n.2109G>A non_coding_transcript_exon_variant 0.2
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.29
rrl 1476392 n.2735A>G non_coding_transcript_exon_variant 0.12
fabG1 1673344 c.-96C>T upstream_gene_variant 0.12
inhA 1674212 p.Leu4Pro missense_variant 0.11
inhA 1674737 p.Ala179Asp missense_variant 0.2
inhA 1674777 c.576C>A synonymous_variant 0.13
inhA 1674867 p.Trp222Cys missense_variant 0.14
rpsA 1833928 c.387G>C synonymous_variant 0.11
rpsA 1834012 c.471G>C synonymous_variant 0.11
rpsA 1834015 c.474G>C synonymous_variant 0.11
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834366 c.825A>G synonymous_variant 0.14
rpsA 1834633 c.1092A>G synonymous_variant 0.17
rpsA 1834639 c.1098T>C synonymous_variant 0.14
rpsA 1834645 c.1104C>T synonymous_variant 0.11
rpsA 1834666 c.1125G>C synonymous_variant 0.13
rpsA 1834667 p.Ala376Ser missense_variant 0.13
rpsA 1834690 c.1149T>C synonymous_variant 0.17
rpsA 1834700 p.Gln387* stop_gained 0.14
rpsA 1834838 p.Glu433* stop_gained 0.17
rpsA 1834860 p.Ala440Val missense_variant 0.2
rpsA 1834896 p.Ser452Ile missense_variant 0.14
rpsA 1834958 p.Leu473Met missense_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918351 p.Gly138Cys missense_variant 0.14
tlyA 1918406 p.Ser156* stop_gained 0.15
ndh 2101699 c.1344G>T synonymous_variant 0.17
ndh 2101980 p.Asn355Asp missense_variant 0.17
ndh 2102281 c.762C>T synonymous_variant 0.13
ndh 2102302 c.741G>C synonymous_variant 0.18
ndh 2102305 p.Gly246Ser missense_variant 0.18
ndh 2102308 c.735G>C synonymous_variant 0.17
ndh 2102320 c.723G>C synonymous_variant 0.15
ndh 2103191 c.-149G>T upstream_gene_variant 0.14
katG 2154642 c.1470C>A synonymous_variant 0.12
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2154827 p.Pro429Thr missense_variant 0.12
katG 2154904 p.Glu403Val missense_variant 0.17
katG 2155723 p.Ala130Val missense_variant 0.18
katG 2155879 p.Arg78Leu missense_variant 0.4
katG 2156430 c.-319G>T upstream_gene_variant 0.2
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169101 c.1512G>T synonymous_variant 0.13
PPE35 2169607 p.Asn336Asp missense_variant 0.11
PPE35 2169634 p.Ala327Thr missense_variant 0.12
PPE35 2170262 c.351C>T synonymous_variant 0.22
PPE35 2170583 c.30C>A synonymous_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289884 c.-643G>T upstream_gene_variant 0.14
pncA 2290131 c.-890G>A upstream_gene_variant 0.14
kasA 2518084 c.-31A>G upstream_gene_variant 0.12
kasA 2518487 p.Ser125Arg missense_variant 0.13
kasA 2518675 p.Met187Ile missense_variant 0.17
kasA 2518805 p.Asp231Tyr missense_variant 0.14
kasA 2519225 p.Leu371Met missense_variant 0.22
kasA 2519272 c.1158C>T synonymous_variant 0.15
kasA 2519364 c.1250G>A splice_region_variant&stop_retained_variant 0.17
eis 2714287 p.Ile349Thr missense_variant 0.11
eis 2714544 p.Glu263Asp missense_variant 0.15
eis 2715532 c.-200G>T upstream_gene_variant 0.2
eis 2715557 c.-225C>A upstream_gene_variant 0.25
folC 2746432 c.1167C>T synonymous_variant 0.14
folC 2746436 p.Asp388Gly missense_variant 0.12
folC 2746758 p.Gly281Ser missense_variant 0.14
folC 2746867 c.732G>T synonymous_variant 0.18
folC 2746995 p.Val202Ile missense_variant 0.13
folC 2747033 p.Ala189Glu missense_variant 0.12
pepQ 2859558 c.861C>A synonymous_variant 0.13
pepQ 2860262 p.Val53Leu missense_variant 0.2
pepQ 2860589 c.-171G>T upstream_gene_variant 0.14
ribD 2986916 c.78C>T synonymous_variant 0.17
ribD 2986997 c.159T>G synonymous_variant 0.12
ribD 2987027 c.189C>A synonymous_variant 0.15
ribD 2987048 c.210C>A synonymous_variant 0.12
ribD 2987134 p.Gly99Val missense_variant 0.18
ribD 2987537 p.Gln233His missense_variant 0.15
Rv2752c 3065129 c.1063C>T synonymous_variant 0.96
Rv2752c 3065496 c.696G>C synonymous_variant 0.15
Rv2752c 3065948 p.Gly82Trp missense_variant 0.12
thyX 3067340 p.Glu202Asp missense_variant 0.2
thyA 3074048 p.Ala142Ser missense_variant 0.12
thyA 3074430 c.42G>T synonymous_variant 0.15
thyA 3074435 p.Glu13* stop_gained 0.15
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086848 p.Lys10Arg missense_variant 0.18
fbiD 3339112 c.-6G>T upstream_gene_variant 0.25
fbiD 3339556 p.Gly147Cys missense_variant 0.2
fbiD 3339628 p.Arg171Ser missense_variant 0.4
Rv3083 3448642 c.139T>C synonymous_variant 0.18
Rv3083 3448874 p.Ala124Glu missense_variant 0.17
Rv3083 3449063 p.Ala187Glu missense_variant 0.2
fprA 3473860 c.-146delT upstream_gene_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474000 c.-7C>A upstream_gene_variant 0.18
fprA 3474594 c.588C>A synonymous_variant 0.13
fprA 3474862 p.Arg286Trp missense_variant 0.15
fprA 3475043 p.Gly346Asp missense_variant 0.22
fprA 3475090 p.Arg362Cys missense_variant 0.22
fprA 3475182 c.1176C>T synonymous_variant 0.18
fprA 3475196 p.Ser397Ile missense_variant 0.18
Rv3236c 3612037 p.Phe360Leu missense_variant 1.0
Rv3236c 3612427 c.690G>A synonymous_variant 0.13
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiA 3640538 c.-5G>A upstream_gene_variant 0.17
fbiA 3640913 p.Pro124His missense_variant 0.12
fbiA 3641161 p.Asp207Tyr missense_variant 0.18
fbiB 3641382 c.-153C>T upstream_gene_variant 0.25
fbiB 3641807 c.273C>A synonymous_variant 0.14
fbiB 3642037 p.Ala168Asp missense_variant 0.33
fbiB 3642125 p.Glu197Asp missense_variant 0.15
fbiB 3642416 c.882G>T synonymous_variant 0.15
alr 3840430 p.Asn331Tyr missense_variant 0.14
alr 3840689 c.732C>A synonymous_variant 0.22
rpoA 3877524 c.984C>A synonymous_variant 0.12
rpoA 3877542 c.966C>A synonymous_variant 0.12
rpoA 3877545 c.963G>T synonymous_variant 0.14
rpoA 3877554 c.954G>A synonymous_variant 0.13
rpoA 3877560 c.948C>T synonymous_variant 0.13
rpoA 3877563 c.945C>T synonymous_variant 0.14
rpoA 3877569 p.Pro313Thr missense_variant 0.17
rpoA 3877587 c.921A>G synonymous_variant 0.11
rpoA 3877638 c.870T>C synonymous_variant 0.12
rpoA 3877656 c.852T>G synonymous_variant 0.12
rpoA 3877729 p.Ser260Tyr missense_variant 0.14
rpoA 3877763 p.Leu249Met missense_variant 0.17
rpoA 3877765 p.Ala248Val missense_variant 0.17
rpoA 3878142 p.Gly122Asp missense_variant 0.14
rpoA 3878160 c.348C>G synonymous_variant 0.18
rpoA 3878163 c.345C>T synonymous_variant 0.18
rpoA 3878169 c.339G>C synonymous_variant 0.18
rpoA 3878184 c.324C>T synonymous_variant 0.18
ddn 3986949 p.Gly36Arg missense_variant 0.11
ddn 3987045 p.Arg68Cys missense_variant 0.12
clpC1 4038354 p.Gln784Leu missense_variant 0.15
clpC1 4038526 p.Ile727Val missense_variant 0.14
clpC1 4039044 p.Pro554Gln missense_variant 0.15
clpC1 4039085 c.1620A>G synonymous_variant 0.17
clpC1 4039091 c.1614G>T synonymous_variant 0.17
clpC1 4039097 c.1608G>T synonymous_variant 0.17
clpC1 4039103 c.1602T>C synonymous_variant 0.17
clpC1 4039106 c.1599G>C synonymous_variant 0.14
clpC1 4039142 c.1563A>G synonymous_variant 0.21
clpC1 4039145 c.1560G>C synonymous_variant 0.21
clpC1 4039169 p.Glu512Asp missense_variant 0.19
clpC1 4039172 c.1533A>G synonymous_variant 0.17
clpC1 4039178 c.1527G>C synonymous_variant 0.17
clpC1 4039183 c.1522T>C synonymous_variant 0.18
clpC1 4039190 c.1515C>T synonymous_variant 0.18
clpC1 4039196 c.1509G>A synonymous_variant 0.14
clpC1 4039199 p.Ala502Glu missense_variant 0.14
clpC1 4039208 c.1497C>G synonymous_variant 0.14
clpC1 4039220 c.1485G>C synonymous_variant 0.14
clpC1 4039625 p.Lys360Asn missense_variant 0.17
clpC1 4039882 p.Glu275Gln missense_variant 0.33
clpC1 4039890 p.Val272Ala missense_variant 0.25
clpC1 4039913 c.792C>T synonymous_variant 0.31
clpC1 4039931 c.774T>C synonymous_variant 0.31
clpC1 4039934 c.771G>C synonymous_variant 0.29
clpC1 4039943 c.762G>C synonymous_variant 0.15
clpC1 4039946 c.759A>G synonymous_variant 0.12
clpC1 4039952 c.753T>C synonymous_variant 0.13
clpC1 4039957 c.748C>T synonymous_variant 0.13
clpC1 4039958 c.747G>C synonymous_variant 0.13
clpC1 4039964 c.741C>G synonymous_variant 0.11
clpC1 4040779 c.-75C>T upstream_gene_variant 0.14
panD 4044059 p.Ala75Thr missense_variant 0.14
panD 4044155 p.Gln43* stop_gained 0.12
panD 4044232 p.Cys17His missense_variant 0.17
panD 4044234 c.48C>G synonymous_variant 0.14
panD 4044249 c.33C>T synonymous_variant 0.12
panD 4044266 p.Leu6Met missense_variant 0.13
panD 4044388 c.-107G>T upstream_gene_variant 0.12
embC 4239898 c.36C>A synonymous_variant 0.18
embC 4239904 c.42A>G synonymous_variant 0.18
embC 4239958 c.96C>T synonymous_variant 0.12
embC 4240015 c.153G>C synonymous_variant 0.14
embC 4240916 p.Ala352Ser missense_variant 0.2
embC 4240963 c.1101G>T synonymous_variant 0.2
embC 4241042 p.Asn394Asp missense_variant 0.12
embC 4241259 p.Arg466Leu missense_variant 0.15
embC 4241924 p.Arg688Gly missense_variant 0.12
embC 4242175 c.2313G>T synonymous_variant 0.25
embC 4242459 p.Ser866Leu missense_variant 0.17
embC 4242536 p.Asp892Tyr missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243737 p.Gln169* stop_gained 0.22
embA 4243779 p.Pro183Ser missense_variant 0.15
embA 4243893 p.Leu221Met missense_variant 0.13
embA 4244903 c.1671G>T synonymous_variant 0.67
embA 4244941 p.Trp570Leu missense_variant 0.2
embA 4244966 c.1734C>T synonymous_variant 0.2
embA 4244976 p.Gly582Arg missense_variant 0.2
embA 4245090 p.Gly620Ser missense_variant 0.12
embA 4245456 p.Glu742Lys missense_variant 0.5
embA 4245558 p.Gly776Cys missense_variant 0.13
embB 4245713 c.-801G>T upstream_gene_variant 0.29
embB 4245716 c.-798G>A upstream_gene_variant 0.29
embA 4245966 p.Phe912Leu missense_variant 0.13
embA 4246096 p.Ala955Asp missense_variant 0.22
embA 4246146 p.Gly972Arg missense_variant 0.18
embB 4247695 c.1182G>T synonymous_variant 0.4
embB 4247790 p.Ser426Ile missense_variant 0.22
embB 4248045 p.Lys511Arg missense_variant 0.12
embB 4248321 p.Gly603Val missense_variant 0.33
embB 4248762 p.Ala750Val missense_variant 0.2
embB 4249037 p.Val842Ile missense_variant 0.2
embB 4249041 p.Pro843Gln missense_variant 0.2
embB 4249260 p.Met916Thr missense_variant 0.13
embB 4249340 p.Ala943Ser missense_variant 0.12
embB 4249683 p.Trp1057* stop_gained 0.25
aftB 4267409 c.1428C>A synonymous_variant 0.13
aftB 4267505 p.Asn444Lys missense_variant 0.22
aftB 4267518 p.Thr440Lys missense_variant 0.29
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4267786 p.Gly351Trp missense_variant 0.17
aftB 4267977 p.Pro287Gln missense_variant 0.2
aftB 4268295 p.Cys181Phe missense_variant 0.17
aftB 4268302 p.Ala179Ser missense_variant 0.17
aftB 4268477 c.360C>G synonymous_variant 0.12
aftB 4268527 c.310C>A synonymous_variant 0.15
aftB 4268551 p.Val96Leu missense_variant 0.12
aftB 4268695 p.Val48Ile missense_variant 0.13
aftB 4269783 c.-947G>T upstream_gene_variant 0.12
ubiA 4269809 p.Pro9Ser missense_variant 0.17
ethA 4326676 p.Ser266Arg missense_variant 0.9
ethA 4326870 p.Val202Phe missense_variant 0.12
ethA 4327905 c.-432C>T upstream_gene_variant 0.14
ethR 4328096 p.Leu183Arg missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 0.93
gid 4407557 c.639_645delAGGGTCG frameshift_variant 0.13
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407854 p.Gly117Trp missense_variant 0.2
gid 4407927 p.Glu92Asp missense_variant 1.0