TB-Profiler result

Run: ERR6866175
Summary

Run ID: ERR6866175

Sample name:

Date: 02-04-2023 03:17:43

Number of reads: 1594488

Percentage reads mapped: 99.44

Strain: lineage4.1.2.1;lineage4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 0.81
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 0.21
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.8
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5133 c.-107A>C upstream_gene_variant 0.24
gyrB 6052 p.Ile271Met missense_variant 0.17
gyrB 7221 p.Ser661Thr missense_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.83
mshA 575679 p.Asn111Ser missense_variant 0.8
rpoB 760115 c.309C>T synonymous_variant 0.68
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765669 p.His767Pro missense_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779107 p.Leu40Val missense_variant 0.85
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416699 p.Leu217Val missense_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1673865 c.-337C>T upstream_gene_variant 0.2
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170642 c.-30C>A upstream_gene_variant 0.84
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.77
eis 2715376 c.-44T>C upstream_gene_variant 0.27
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249408 c.2895G>A synonymous_variant 0.13
aftB 4267207 p.Val544Met missense_variant 0.84
whiB6 4338595 c.-75delG upstream_gene_variant 1.0