TB-Profiler result

Run: SRR1166208

Summary

Run ID: SRR1166208

Sample name:

Date: 15-08-2022 02:21:14

Number of reads: 9465653

Percentage reads mapped: 99.66

Strain: lineage4.8

Drug-resistance: Pre-XDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Ala missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289156 c.85dupC frameshift_variant 1.0 pyrazinamide
eis 2715369 c.-37G>T upstream_gene_variant 1.0 kanamycin
embA 4243217 c.-16C>T upstream_gene_variant 1.0 ethambutol
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
ethA 4326288 c.1185dupC frameshift_variant 0.15 ethionamide
ethA 4326787 c.686_687insA frameshift_variant 0.13 ethionamide
ethA 4326801 c.672dupG frameshift_variant 0.21 ethionamide
ethA 4326911 c.562dupG frameshift_variant 0.21 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoC 766487 p.Pro1040Ser missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.99
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3064515 c.1677A>C stop_lost&splice_region_variant 1.0
ald 3087228 p.Ala137Thr missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4248694 c.2181G>A synonymous_variant 1.0
ethA 4327052 p.Tyr141Cys missense_variant 1.0
ethA 4327409 p.His22Arg missense_variant 0.09
ethR 4327974 p.Met142Ile missense_variant 1.0
ethR 4327975 p.Gln143Lys missense_variant 1.0
whiB6 4338269 c.252delA frameshift_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448508 c.6_*1407del frameshift_variant&stop_lost&splice_region_variant 1.0