TB-Profiler result

Run: SRR21277802
Summary

Run ID: SRR21277802

Sample name:

Date: 04-04-2023 01:43:59

Number of reads: 16062273

Percentage reads mapped: 97.47

Strain: lineage2.2.1.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
lineage2.2.1.1 East-Asian (Beijing) Beijing-RD150 RD105;RD207;RD181;RD150 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575424 p.Arg26Leu missense_variant 0.1
mshA 575479 c.132G>T synonymous_variant 0.12
mshA 575866 c.519G>A synonymous_variant 0.12
mshA 575877 p.Ala177Glu missense_variant 0.12
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620000 p.Ala37Asp missense_variant 0.14
ccsA 620149 p.Gly87Cys missense_variant 0.11
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 777299 c.1182G>T synonymous_variant 0.11
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303117 p.Ala63Thr missense_variant 0.17
fbiC 1304181 c.1251G>A synonymous_variant 0.12
fbiC 1304246 p.Asp439Val missense_variant 0.12
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1406991 p.Gly117Val missense_variant 0.25
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1917978 c.39G>A synonymous_variant 0.11
tlyA 1918573 p.Ala212Thr missense_variant 0.23
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155740 p.Gly124Val missense_variant 0.1
katG 2155743 c.369G>T synonymous_variant 0.18
katG 2155747 p.Ala122Val missense_variant 0.13
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170081 p.Leu178Met missense_variant 0.5
PPE35 2170091 c.522T>A synonymous_variant 0.11
PPE35 2170103 c.510C>A synonymous_variant 0.11
PPE35 2170363 p.Glu84* stop_gained 0.17
PPE35 2170401 p.Pro71Gln missense_variant 0.27
PPE35 2170403 c.210C>A synonymous_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518871 p.His253Tyr missense_variant 1.0
kasA 2519075 p.Ala321Thr missense_variant 0.29
kasA 2519152 c.1038G>T synonymous_variant 0.11
eis 2714846 p.Val163Ile missense_variant 1.0
folC 2746614 p.Gly329Cys missense_variant 0.11
pepQ 2859605 p.Gly272Trp missense_variant 0.16
pepQ 2859920 p.Arg167* stop_gained 0.11
pepQ 2859937 p.Gly161Asp missense_variant 0.2
pepQ 2859940 p.Arg160His missense_variant 0.12
pepQ 2860161 c.258G>T synonymous_variant 0.22
pepQ 2860589 c.-171G>T upstream_gene_variant 0.23
thyX 3067431 p.Arg172Leu missense_variant 0.12
thyX 3067444 p.Arg168Cys missense_variant 0.12
thyX 3067539 p.Ala136Asp missense_variant 0.1
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087338 c.519G>T synonymous_variant 0.11
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.99
fbiB 3641923 p.Ala130Glu missense_variant 0.11
fbiB 3642009 p.Gly159Cys missense_variant 0.12
alr 3841030 p.Ala131Ser missense_variant 0.1
alr 3841044 p.Ala126Val missense_variant 0.13
embC 4242395 p.Pro845Thr missense_variant 0.15
embC 4242527 p.Gly889Trp missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243594 p.Ser121Leu missense_variant 0.11
embA 4243608 p.Ala126Ser missense_variant 0.12
embA 4243678 p.Gly149Val missense_variant 1.0
embA 4243909 p.Arg226Gln missense_variant 0.1
embA 4244277 p.Pro349Ser missense_variant 0.12
embA 4244283 p.Pro351Ser missense_variant 0.11
embA 4244495 c.1263G>A synonymous_variant 0.21
embA 4244580 p.Asp450Tyr missense_variant 0.13
embA 4244865 p.Ala545Thr missense_variant 0.11
embB 4246729 c.216C>A synonymous_variant 0.13
embB 4246792 c.279C>A synonymous_variant 0.13
embB 4247032 c.519C>A synonymous_variant 0.16
embB 4247639 p.Ala376Ser missense_variant 0.1
embB 4247869 c.1356G>A synonymous_variant 0.2
embB 4248115 c.1602C>T synonymous_variant 1.0
embB 4248594 p.Gly694Val missense_variant 0.11
aftB 4267647 p.Asp397Gly missense_variant 1.0
ethA 4328468 c.-995T>A upstream_gene_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0