TB-Profiler result

Run: SRR21700925
Summary

Run ID: SRR21700925

Sample name:

Date: 2025-03-05T00:40:42.813143

Number of reads: 8300949

Percentage reads mapped: 99.97

Median coverage: 283.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embA c.-16C>T Uncertain significance Mutation from literature
c.-12C>T Uncertain significance Mutation from literature: doi: 10.1128/AAC.03285-14
embB p.Gln497Lys Assoc w R
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embA 4243217 c.-16C>T upstream_gene_variant 0.23 ethambutol Uncertain significance Mutation from literature
embA 4243221 c.-12C>T upstream_gene_variant 0.24 ethambutol Uncertain significance Mutation from literature: doi: 10.1128/AAC.03285-14
embB 4248002 p.Gln497Lys missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
Rv1258c 1406686 p.Val219Ile missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
embB 4247028 p.Leu172Arg missense_variant 0.14 ethambutol Uncertain significance
embB 4247039 p.Phe176Val missense_variant 0.14 ethambutol Uncertain significance
ubiA 4269721 p.Ala38Val missense_variant 0.99 ethambutol Uncertain significance