Run ID: SRR22528542
Sample name:
Date: 04-04-2023 04:18:23
Number of reads: 3090796
Percentage reads mapped: 99.74
Strain: lineage4.4.1.1;lineage2.2.1
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage2 | East-Asian | Beijing | RD105 | 0.07 |
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.4 | Euro-American | S;T | None | 0.91 |
lineage2.2.1 | East-Asian (Beijing) | Beijing-RD181 | RD105;RD207;RD181 | 0.06 |
lineage4.4.1 | Euro-American (S-type) | S;T | None | 0.91 |
lineage4.4.1.1 | Euro-American | S;Orphans | None | 0.9 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.95 | rifampicin |
rpsL | 781687 | p.Lys43Arg | missense_variant | 0.89 | streptomycin |
katG | 2155168 | p.Ser315Thr | missense_variant | 0.88 | isoniazid |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 8116 | p.Thr272Ile | missense_variant | 0.91 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.12 |
ccsA | 620625 | p.Ile245Met | missense_variant | 0.13 |
rpoB | 761528 | p.Asp574Glu | missense_variant | 0.93 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 0.11 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
ndh | 2102990 | p.Val18Ala | missense_variant | 0.86 |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.11 |
PPE35 | 2169840 | p.Gly258Asp | missense_variant | 0.91 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
pepQ | 2860144 | p.Val92Gly | missense_variant | 0.13 |
thyA | 3074495 | c.-24C>T | upstream_gene_variant | 0.91 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
ald | 3087828 | p.Pro337Thr | missense_variant | 0.2 |
Rv3083 | 3448608 | c.105G>A | synonymous_variant | 0.86 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
whiB7 | 3568425 | c.255T>G | synonymous_variant | 0.17 |
whiB7 | 3568428 | c.252A>G | synonymous_variant | 0.22 |
whiB7 | 3568437 | c.243T>C | synonymous_variant | 0.17 |
whiB7 | 3568441 | p.Lys80Thr | missense_variant | 0.11 |
Rv3236c | 3612665 | p.Val151Ala | missense_variant | 0.89 |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.16 |
rpoA | 3878637 | c.-130G>C | upstream_gene_variant | 0.14 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embA | 4244970 | c.1738C>T | synonymous_variant | 0.91 |
embB | 4247028 | p.Leu172Arg | missense_variant | 0.19 |
embB | 4247033 | p.Ser174Arg | missense_variant | 0.15 |
embB | 4247039 | p.Phe176Val | missense_variant | 0.17 |
embB | 4247055 | p.Leu181Gln | missense_variant | 0.18 |
embB | 4248437 | p.Thr642Ala | missense_variant | 0.85 |
ethR | 4326703 | c.-846T>C | upstream_gene_variant | 0.91 |
whiB6 | 4338514 | p.Tyr3Cys | missense_variant | 0.9 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.11 |