TB-Profiler result

Run: SRR23650981
Summary

Run ID: SRR23650981

Sample name:

Date: 03-02-2024 06:46:05

Number of reads: 11266431

Percentage reads mapped: 99.94

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid R katG p.Lys414Asn (0.38), katG p.Asn138Ser (0.41)
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2154870 p.Lys414Asn missense_variant 0.38 isoniazid
katG 2155699 p.Asn138Ser missense_variant 0.41 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476561 n.2904C>T non_coding_transcript_exon_variant 0.29
katG 2155627 p.Ala162Glu missense_variant 0.18
ahpC 2726121 c.-72C>T upstream_gene_variant 0.38
ahpC 2726213 c.21C>A synonymous_variant 0.14
rpoA 3878614 c.-107A>C upstream_gene_variant 0.15
embB 4247028 p.Leu172Arg missense_variant 0.21
embB 4247033 p.Ser174Arg missense_variant 0.17