TB-Profiler result

Run: SRR28393833
Summary

Run ID: SRR28393833

Sample name:

Date: 2024-10-05T09:27:53.646116

Number of reads: 2686771

Percentage reads mapped: 99.62

Median coverage: 79.0

Strain: lineage4.1.2;lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.31
lineage4.1.2 Euro-American None 0.3
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.69
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 260 p.Ser87Ile missense_variant 0.69 isoniazid Uncertain significance
dnaA 371 p.Pro124Leu missense_variant 0.66 isoniazid Not assoc w R
dnaA 449 p.Tyr150Cys missense_variant 0.7 isoniazid Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.24 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.29 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.29 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.31 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 764263 c.894G>A synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 0.25 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 0.98 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 778227 p.Gly85Glu missense_variant 0.36 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800200 c.-609C>G upstream_gene_variant 0.33 linezolid
Rv1129c 1253097 p.Ser480Pro missense_variant 0.34 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
atpE 1460992 c.-53A>C upstream_gene_variant 0.81 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.23 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>T upstream_gene_variant 0.24 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 0.36 isoniazid
ahpC 2726100 c.-93G>C upstream_gene_variant 0.6 isoniazid Uncertain significance
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.17 capreomycin Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 0.29 cycloserine
ald 3087026 p.Asp69Glu missense_variant 0.71 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.27 rifampicin Not assoc w R
bedaquiline Uncertain significance
alr 3840764 c.657G>C synonymous_variant 0.55 cycloserine
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.28 ethambutol Not assoc w R
embB 4248705 p.Pro731Leu missense_variant 0.31 ethambutol Uncertain significance
ethA 4326172 c.1302C>T synonymous_variant 0.39 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.27 kanamycin
capreomycin
amikacin