TB-Profiler result

Run: SRR4033750
Summary

Run ID: SRR4033750

Sample name:

Date: 04-04-2023 06:18:16

Number of reads: 1389404

Percentage reads mapped: 99.51

Strain: lineage2.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5936 p.Ala233Thr missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 619984 p.Leu32Met missense_variant 0.17
ccsA 620625 p.Ile245Met missense_variant 1.0
ccsA 620760 c.870C>G synonymous_variant 1.0
rpoB 760944 c.1142delA frameshift_variant 0.13
rpoB 762523 c.2720_2722dupTGG disruptive_inframe_insertion 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763935 p.Ala189Val missense_variant 0.11
rpoC 764491 c.1122G>A synonymous_variant 1.0
rpoC 765173 p.Ala602Thr missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781619 p.Lys20Asn missense_variant 0.11
rplC 801432 c.624C>A synonymous_variant 0.11
fbiC 1303987 p.Asp353Tyr missense_variant 0.14
fbiC 1304467 p.Glu513* stop_gained 0.13
fbiC 1305055 c.2126delT frameshift_variant 0.13
fbiC 1305216 c.2286C>T synonymous_variant 0.12
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1406998 p.Ala115Thr missense_variant 0.12
embR 1416705 c.642delC frameshift_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474978 n.1321A>T non_coding_transcript_exon_variant 0.13
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102052 p.Gly331Cys missense_variant 0.12
ndh 2102475 p.Ala190Thr missense_variant 0.12
katG 2153933 p.Ala727Ser missense_variant 0.18
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.3
PPE35 2170346 p.Gln89His missense_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288719 c.520_522delGAG conservative_inframe_deletion 0.15
folC 2747167 p.Lys144Asn missense_variant 1.0
folC 2747353 c.246C>A synonymous_variant 0.14
folC 2747427 p.Gly58Cys missense_variant 0.18
folC 2747579 p.Gly7Asp missense_variant 0.12
pepQ 2859565 p.Gly285Asp missense_variant 0.17
ribD 2987307 p.Ala157Pro missense_variant 0.29
ribD 2987505 p.Leu223Met missense_variant 0.18
Rv2752c 3066237 c.-46C>A upstream_gene_variant 0.12
Rv2752c 3066329 c.-138C>A upstream_gene_variant 0.12
thyX 3067561 c.384delG frameshift_variant 0.22
ald 3086739 c.-81G>A upstream_gene_variant 0.96
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474688 p.Ala228Thr missense_variant 0.18
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3641957 c.423C>A synonymous_variant 0.4
fbiB 3642369 p.Ala279Thr missense_variant 0.13
clpC1 4038396 c.2308dupG frameshift_variant 0.13
clpC1 4038857 c.1848C>A synonymous_variant 0.17
embC 4240435 c.573C>T synonymous_variant 0.15
embC 4241528 p.Arg556Cys missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4246109 c.-405C>T upstream_gene_variant 0.12
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268499 p.Arg113His missense_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0