Run ID: SRR6797765
Sample name:
Date: 04-04-2023 16:17:20
Number of reads: 1344072
Percentage reads mapped: 99.46
Strain: lineage4.8
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.8 | Euro-American (mainly T) | T1;T2;T3;T5 | RD219 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2288886 | p.Trp119* | stop_gained | 0.48 | pyrazinamide |
embB | 4247431 | p.Met306Ile | missense_variant | 0.96 | ethambutol |
embB | 4247729 | p.Gly406Ser | missense_variant | 1.0 | ethambutol |
gid | 4407908 | p.Glu99* | stop_gained | 1.0 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 1.0 |
rrl | 1475105 | n.1448G>A | non_coding_transcript_exon_variant | 0.1 |
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.12 |
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.12 |
inhA | 1674745 | p.Tyr182His | missense_variant | 0.13 |
rpsA | 1834918 | c.1377C>A | synonymous_variant | 0.14 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2168149 | p.Pro822Ser | missense_variant | 1.0 |
PPE35 | 2170048 | p.Leu189Val | missense_variant | 0.31 |
PPE35 | 2170053 | p.Thr187Ser | missense_variant | 0.3 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
clpC1 | 4039729 | p.Asp326Asn | missense_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
Rv3083 | 3448507 | c.5_*1408del | frameshift_variant&stop_lost&splice_region_variant | 1.0 |