TB-Profiler result

Run: SRR6982547
Summary

Run ID: SRR6982547

Sample name:

Date: 2024-10-05T10:34:18.355097

Number of reads: 1771319

Percentage reads mapped: 99.55

Median coverage: 74.0

Strain: lineage4.3.3;lineage4.8.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.21
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.79
lineage4.8.1 Euro-American (mainly T) RD219 0.81
lineage4.3.3 Euro-American (LAM) RD115 0.17
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.12 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 0.27 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.26 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575909 p.Leu188Val missense_variant 0.16 isoniazid Uncertain significance
ethionamide Uncertain significance
rpoC 764995 c.1626C>G synonymous_variant 0.13 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 778346 c.135C>T synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.25 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2168149 p.Pro822Ser missense_variant 0.69 pyrazinamide Not assoc w R
PPE35 2170892 c.-280G>A upstream_gene_variant 0.82 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518919 p.Gly269Ser missense_variant 0.14 isoniazid
folC 2747225 p.Arg125Gln missense_variant 0.15 para-aminosalicylic_acid
Rv2680 2995848 c.-257G>A upstream_gene_variant 0.83 capreomycin
thyA 3073868 p.Thr202Ala missense_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.24 cycloserine
fbiD 3339040 c.-78T>C upstream_gene_variant 0.79 pretomanid
delamanid
clofazimine
mtrB 3625065 p.Met517Leu missense_variant 0.34 rifampicin Not assoc w R
bedaquiline Uncertain significance
fbiB 3642874 p.Leu447Arg missense_variant 0.74 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
clpC1 4038287 c.2418C>T synonymous_variant 0.24 pyrazinamide Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338367 p.Leu52Gln missense_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.21 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 0.24 streptomycin Not assoc w R