TB-Profiler result

Run: SRR8692805
Summary

Run ID: SRR8692805

Sample name:

Date: 13-08-2023 20:48:48

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.9;lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.09
lineage4 Euro-American LAM;T;S;X;H None 0.85
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.15
lineage4.9 Euro-American (H37Rv-like) T1 None 0.86
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.07
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rplC 801268 p.Cys154Arg missense_variant 0.88 linezolid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 0.19
gyrA 7585 p.Ser95Thr missense_variant 0.11
fgd1 491742 c.960T>C synonymous_variant 0.18
ccsA 620625 p.Ile245Met missense_variant 0.12
rpoC 763031 c.-339T>C upstream_gene_variant 0.19
mmpL5 776100 p.Thr794Ile missense_variant 0.15
mmpL5 776182 p.Asp767Asn missense_variant 0.2
mmpS5 779615 c.-710C>G upstream_gene_variant 0.1
rpsL 781395 c.-165T>C upstream_gene_variant 0.16
Rv1258c 1406686 p.Val219Ile missense_variant 0.89
Rv1258c 1406760 c.580_581insC frameshift_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474670 n.1013C>A non_coding_transcript_exon_variant 0.11
rrl 1474729 n.1072G>T non_coding_transcript_exon_variant 0.12
inhA 1674210 c.9A>C synonymous_variant 0.14
rpsA 1834177 c.636A>C synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 0.17
PPE35 2167926 p.Leu896Ser missense_variant 0.11
Rv3236c 3612813 p.Thr102Ala missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 0.3
whiB6 4338595 c.-75delG upstream_gene_variant 0.17
gid 4407588 c.615A>G synonymous_variant 0.24
gid 4407927 p.Glu92Asp missense_variant 0.18