TB-Profiler result

Run: ERR046812
Summary

Run ID: ERR046812

Sample name:

Date: 31-03-2023 08:51:55

Number of reads: 4647517

Percentage reads mapped: 99.39

Strain: lineage3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7799 c.498A>C synonymous_variant 0.17
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576751 p.Lys468Asn missense_variant 0.16
rpoB 759620 c.-187A>C upstream_gene_variant 0.29
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 762249 p.Leu815Val missense_variant 0.21
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.22
rpoC 763031 c.-339T>C upstream_gene_variant 0.99
rpoC 764725 p.Phe452Leu missense_variant 0.27
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.2
Rv1258c 1406750 c.591C>A synonymous_variant 0.19
embR 1417136 p.Ser71Ile missense_variant 0.18
atpE 1461019 c.-26C>A upstream_gene_variant 0.19
rrs 1471658 n.-188T>G upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476408 n.2751G>C non_coding_transcript_exon_variant 0.16
inhA 1674892 p.Asn231Asp missense_variant 0.25
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.25
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167871 c.2742G>C synonymous_variant 0.22
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169379 p.Phe412Val missense_variant 0.23
PPE35 2169866 c.747G>C synonymous_variant 0.43
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.16
ahpC 2725954 c.-239C>T upstream_gene_variant 0.33
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ahpC 2726756 c.564C>G synonymous_variant 0.24
pepQ 2859381 c.1038C>G synonymous_variant 0.15
Rv2752c 3064552 p.Arg547Pro missense_variant 0.19
Rv2752c 3064741 p.Gly484Ala missense_variant 0.21
thyX 3068151 c.-206T>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339153 p.Leu12Phe missense_variant 0.17
fbiD 3339273 c.156T>G synonymous_variant 0.26
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.26
fbiB 3642734 c.1200G>C synonymous_variant 0.21
alr 3841473 c.-53G>A upstream_gene_variant 1.0
ddn 3987013 p.Gly57Ala missense_variant 0.27
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039932 p.Gly258Val missense_variant 0.23
embC 4239973 c.111T>G synonymous_variant 0.24
embC 4241056 c.1194C>G synonymous_variant 0.26
embC 4241456 p.Ala532Pro missense_variant 0.3
embC 4242075 p.Arg738Gln missense_variant 1.0
embC 4242425 p.Arg855Gly missense_variant 0.12
embC 4242476 p.Pro872Ala missense_variant 0.19
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.21
embA 4243977 p.Ala249Pro missense_variant 0.28
embB 4248725 p.Ser738Ala missense_variant 0.25
ubiA 4269529 p.Ala102Gly missense_variant 0.24
ethA 4327672 c.-199G>A upstream_gene_variant 0.4
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0