Run ID: ERR1082139
Sample name:
Date: 2025-05-07T04:04:30.060828
Number of reads: 5296591
Percentage reads mapped: 99.38
Median coverage: 146.0
Strain: lineage5.1
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage5 | West-Africa 1 | RD711 | 1.0 |
| lineage5.1 | West-Africa 1 | RD711 | 0.92 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 6446 | p.Ala403Ser | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9566 | c.2265C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| Rv0010c | 13579 | c.-21G>A | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| delamanid | Not assoc w R - Interim | |||||
| pretomanid | Uncertain significance | |||||
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| hadA | 731750 | c.-180G>C | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 0.99 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| moxifloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| delamanid | Uncertain significance | |||||
| pretomanid | Uncertain significance | |||||
| Rv1258c | 1407273 | p.Asp23Val | missense_variant | 1.0 | isoniazid | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | amikacin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| inhA | 1673338 | c.-864G>A | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| tsnR | 1853565 | c.-41G>A | upstream_gene_variant | 1.0 | linezolid | Uncertain significance |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | amikacin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| bacA | 2063187 | c.1542C>T | synonymous_variant | 1.0 | amikacin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R | |||||
| streptomycin | Not assoc w R - Interim | |||||
| ndh | 2101921 | c.1122G>A | synonymous_variant | 1.0 | delamanid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| ndh | 2103112 | c.-70G>T | upstream_gene_variant | 1.0 | delamanid | Uncertain significance |
| ethionamide | Uncertain significance | |||||
| isoniazid | Not assoc w R - Interim | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| Rv1979c | 2223759 | c.-596delC | upstream_gene_variant | 1.0 | bedaquiline | Uncertain significance |
| clofazimine | Uncertain significance | |||||
| pncA | 2290062 | c.-821G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | Uncertain significance |
| Rv2477c | 2784071 | c.-29C>T | upstream_gene_variant | 1.0 | amikacin | Uncertain significance |
| ethambutol | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| moxifloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| Rv2477c | 2784160 | c.-526_-119del | upstream_gene_variant | 1.0 | amikacin | Uncertain significance |
| ethambutol | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| moxifloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | Uncertain significance |
| ald | 3087184 | c.368_373delCCGACG | disruptive_inframe_deletion | 1.0 | cycloserine | Uncertain significance |
| lpqB | 3624350 | c.561G>T | synonymous_variant | 0.99 | bedaquiline | Not assoc w R - Interim |
| rifampicin | Not assoc w R | |||||
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| alr | 3840932 | c.489C>T | synonymous_variant | 1.0 | cycloserine | Uncertain significance |
| ddn | 3986987 | c.144G>T | synonymous_variant | 1.0 | delamanid | Not assoc w R - Interim |
| pretomanid | Uncertain significance | |||||
| ddn | 3987180 | p.Asp113Asn | missense_variant | 1.0 | delamanid | Uncertain significance |
| pretomanid | Uncertain significance | |||||
| clpC1 | 4040321 | c.384C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040824 | c.-120C>T | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4045054 | c.-773G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| isoniazid | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| moxifloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| glpK | 4139131 | p.Glu209Lys | missense_variant | 1.0 | ethambutol | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| moxifloxacin | Uncertain significance | |||||
| rifampicin | Not assoc w R | |||||
| streptomycin | Uncertain significance | |||||
| embC | 4239843 | c.-20A>C | upstream_gene_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4244220 | c.988C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4244635 | p.Val468Ala | missense_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245147 | p.Pro639Ser | missense_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ethA | 4326928 | c.546C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4327103 | p.Gly124Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | amikacin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | amikacin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
