TB-Profiler result

Run: ERR11466505
Summary

Run ID: ERR11466505

Sample name:

Date: 08-01-2024 09:07:02

Number of reads: 4752566

Percentage reads mapped: 99.86

Strain: lineage4.9.1;lineage4.4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 0.69
lineage4.4 Euro-American S;T None 0.32
lineage4.9.1 Euro-American (H37Rv-like) T1 None 0.69
lineage4.4.1 Euro-American (S-type) S;T None 0.34
lineage4.4.1.1 Euro-American S;Orphans None 0.31
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.29
gyrA 8978 c.1677C>T synonymous_variant 0.62
gyrA 9138 p.Gln613Glu missense_variant 0.28
gyrA 9304 p.Gly668Asp missense_variant 0.3
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777416 c.1065G>T synonymous_variant 0.28
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 0.29
PPE35 2168479 p.Thr712Pro missense_variant 0.27
PPE35 2169840 p.Gly258Asp missense_variant 0.32
PPE35 2169902 p.Leu237Phe missense_variant 0.23
PPE35 2169910 p.Asn235Tyr missense_variant 0.23
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 0.73
ald 3086788 c.-32T>C upstream_gene_variant 0.25
fbiD 3339385 p.Asp90Asn missense_variant 0.67
Rv3083 3448608 c.105G>A synonymous_variant 0.37
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.28
fprA 3474144 p.Trp46Cys missense_variant 0.16
whiB7 3568779 c.-100T>C upstream_gene_variant 0.28
Rv3236c 3612665 p.Val151Ala missense_variant 0.28
embA 4242643 c.-590C>T upstream_gene_variant 0.26
whiB6 4338595 c.-75delG upstream_gene_variant 1.0