TB-Profiler

TB-Profiler result

Run: ERR13265746

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: ERR13265746

Sample name:

Date: 2025-02-11T10:08:59.658524

Number of reads: 18092

Percentage reads mapped: 60.61

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
fgd1	491491	p.Pro237Thr	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491499	c.717G>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491502	p.Glu240Asp	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491505	c.723G>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491508	c.726A>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491509	c.727T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491512	p.Asn244Glu	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491520	c.738C>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491523	c.741G>T	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fgd1	491526	c.744T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491542	c.760T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491547	c.765A>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491550	c.768T>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491553	c.771G>A	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491569	p.Asp263Thr	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491583	c.801G>A	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491590	p.Lys270Glu	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491595	c.813C>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491601	c.819T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine