TB-Profiler result

Run: ERR1750907
Summary

Run ID: ERR1750907

Sample name:

Date: 31-03-2023 14:59:24

Number of reads: 668712

Percentage reads mapped: 62.82

Strain:

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.29 rifampicin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.86 kanamycin, capreomycin, aminoglycosides, amikacin
tlyA 1918494 c.556delG frameshift_variant 0.4 capreomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5405 p.Glu56* stop_gained 0.67
gyrB 5487 p.Gly83Val missense_variant 0.67
gyrA 6922 c.-380G>T upstream_gene_variant 0.5
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9794 p.Asn831Lys missense_variant 1.0
fgd1 490686 c.-97G>A upstream_gene_variant 0.15
mshA 575414 p.Gly23Cys missense_variant 0.15
mshA 575433 p.Gly29Asp missense_variant 0.17
mshA 575952 p.Gly202Glu missense_variant 0.18
ccsA 620699 p.Val270Asp missense_variant 0.25
ccsA 620712 c.822G>A synonymous_variant 0.2
rpoB 759620 c.-187A>C upstream_gene_variant 0.67
rpoB 760827 p.Arg341Cys missense_variant 1.0
rpoB 760903 p.His366Leu missense_variant 0.67
rpoB 760962 p.Gly386Cys missense_variant 0.67
rpoB 760985 c.1179G>C synonymous_variant 0.5
rpoB 760991 c.1185G>C synonymous_variant 0.67
rpoB 760997 c.1191G>C synonymous_variant 0.6
rpoB 761006 c.1200C>G synonymous_variant 0.4
rpoB 761013 p.Val403Ile missense_variant 0.4
rpoB 761027 c.1221A>G synonymous_variant 0.5
rpoB 761036 c.1230G>C synonymous_variant 0.75
rpoB 761037 c.1231T>C synonymous_variant 0.75
rpoB 761046 p.Ile414Val missense_variant 0.5
rpoB 761051 c.1245G>C synonymous_variant 0.67
rpoB 761054 c.1248G>C synonymous_variant 0.75
rpoB 761057 c.1251G>C synonymous_variant 0.75
rpoB 761087 c.1281C>A synonymous_variant 0.33
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.33
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.5
rpoB 761102 c.1296A>G synonymous_variant 0.38
rpoB 761120 c.1314C>T synonymous_variant 0.25
rpoB 761126 c.1320G>C synonymous_variant 0.25
rpoB 761132 c.1326G>T synonymous_variant 0.29
rpoB 761133 c.1327T>C synonymous_variant 0.29
rpoB 761149 p.Arg448Leu missense_variant 0.29
rpoB 761162 c.1356G>C synonymous_variant 0.29
rpoB 761165 c.1359G>C synonymous_variant 0.25
rpoB 761174 c.1368T>C synonymous_variant 0.25
rpoB 761239 p.Cys478Phe missense_variant 0.25
rpoB 761251 p.Thr482Asn missense_variant 0.33
rpoB 761933 c.2127G>C synonymous_variant 0.4
rpoB 761948 c.2142G>C synonymous_variant 0.67
rpoB 761954 c.2148C>G synonymous_variant 0.67
rpoB 761972 c.2166C>T synonymous_variant 1.0
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.67
rpoB 762003 p.Asn733Gln missense_variant 0.67
rpoB 762008 c.2202C>T synonymous_variant 0.67
rpoB 762011 c.2205G>C synonymous_variant 0.67
rpoB 762053 c.2247T>C synonymous_variant 0.67
rpoB 762062 c.2256T>C synonymous_variant 0.6
rpoB 762065 c.2259T>C synonymous_variant 0.6
rpoB 762080 c.2274G>C synonymous_variant 0.6
rpoB 762086 c.2280G>C synonymous_variant 0.6
rpoB 762101 c.2295C>G synonymous_variant 0.33
rpoB 762114 p.Ile770Val missense_variant 0.33
rpoB 762137 c.2331C>T synonymous_variant 0.25
rpoB 762140 c.2334G>C synonymous_variant 0.25
rpoB 762143 c.2337T>C synonymous_variant 0.25
rpoB 762149 c.2343G>C synonymous_variant 0.25
rpoB 762161 c.2355C>T synonymous_variant 0.25
rpoB 762176 c.2370T>C synonymous_variant 0.25
rpoB 762184 p.Gly793Val missense_variant 0.29
rpoB 762218 c.2412T>C synonymous_variant 0.25
rpoB 762233 c.2427G>C synonymous_variant 0.25
rpoB 762239 c.2433G>A synonymous_variant 0.25
rpoB 762245 c.2439G>T synonymous_variant 0.25
rpoB 762433 p.Gly876Asp missense_variant 0.67
rpoC 762923 c.-447C>G upstream_gene_variant 0.67
rpoC 762962 c.-408C>T upstream_gene_variant 0.4
rpoC 762989 c.-381G>C upstream_gene_variant 0.5
rpoC 763028 c.-342T>C upstream_gene_variant 0.5
rpoC 763031 c.-339T>C upstream_gene_variant 0.75
rpoC 763034 c.-336C>G upstream_gene_variant 0.5
rpoC 763040 c.-330C>G upstream_gene_variant 1.0
rpoC 763053 c.-317T>C upstream_gene_variant 1.0
rpoC 763058 c.-312C>G upstream_gene_variant 1.0
rpoC 763070 c.-300T>C upstream_gene_variant 1.0
rpoC 763094 c.-276G>C upstream_gene_variant 1.0
rpoC 763115 c.-255T>C upstream_gene_variant 1.0
rpoC 763642 c.273G>C synonymous_variant 0.5
rpoC 763660 c.291T>C synonymous_variant 0.5
rpoC 763696 c.327T>C synonymous_variant 0.29
rpoC 763708 c.339G>C synonymous_variant 0.33
rpoC 763711 c.342G>C synonymous_variant 0.29
rpoC 763717 c.348T>C synonymous_variant 0.29
rpoC 763727 p.Leu120Met missense_variant 0.29
rpoC 763732 c.363C>G synonymous_variant 0.29
rpoC 763744 c.375G>C synonymous_variant 0.29
rpoC 764353 c.984G>C synonymous_variant 0.33
rpoC 764365 c.996C>T synonymous_variant 0.33
rpoC 764371 c.1002G>C synonymous_variant 0.33
rpoC 764380 c.1011G>C synonymous_variant 0.5
rpoC 764387 c.1018T>C synonymous_variant 0.5
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.6
rpoC 764410 c.1041G>C synonymous_variant 0.4
rpoC 764428 c.1059G>C synonymous_variant 0.4
rpoC 764431 c.1062G>C synonymous_variant 0.6
rpoC 764434 c.1065A>G synonymous_variant 0.5
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.6
rpoC 764446 c.1077T>C synonymous_variant 0.33
rpoC 764449 c.1080G>C synonymous_variant 0.5
rpoC 764458 c.1089G>C synonymous_variant 0.43
rpoC 764461 c.1092A>G synonymous_variant 0.57
rpoC 764470 c.1101C>G synonymous_variant 0.25
rpoC 764497 c.1128A>G synonymous_variant 0.6
rpoC 764498 p.Ser377Ala missense_variant 0.5
rpoC 764503 c.1134G>C synonymous_variant 0.6
rpoC 764509 c.1140G>C synonymous_variant 0.2
rpoC 764521 c.1152T>C synonymous_variant 0.55
rpoC 764533 c.1164C>T synonymous_variant 0.33
rpoC 764536 c.1167G>T synonymous_variant 0.44
rpoC 764539 c.1170C>G synonymous_variant 0.18
rpoC 764548 c.1179G>T synonymous_variant 0.5
rpoC 764549 p.Pro394Thr missense_variant 0.36
rpoC 764560 c.1191T>G synonymous_variant 0.2
rpoC 764561 p.Pro398Ala missense_variant 0.36
rpoC 764566 c.1197C>G synonymous_variant 0.2
rpoC 764572 c.1203G>C synonymous_variant 0.2
rpoC 764575 c.1206T>G synonymous_variant 0.38
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.25
rpoC 764581 c.1212T>C synonymous_variant 0.38
rpoC 764582 p.Leu405Met missense_variant 0.38
rpoC 764593 c.1224C>A synonymous_variant 0.25
rpoC 764602 c.1233C>T synonymous_variant 0.25
rpoC 764605 c.1236G>C synonymous_variant 0.22
rpoC 764611 c.1242G>C synonymous_variant 0.33
rpoC 764632 c.1263T>C synonymous_variant 0.33
rpoC 764635 c.1266C>G synonymous_variant 0.33
rpoC 764644 c.1275G>C synonymous_variant 0.22
rpoC 764650 c.1281G>T synonymous_variant 0.25
rpoC 764662 c.1293G>C synonymous_variant 0.25
rpoC 764683 c.1314G>C synonymous_variant 0.38
rpoC 764692 c.1323C>T synonymous_variant 0.22
rpoC 764705 p.Leu446Ala missense_variant 0.22
rpoC 764716 c.1347G>C synonymous_variant 0.33
rpoC 765150 p.Gly594Glu missense_variant 0.75
rpoC 765252 p.Ser628Asn missense_variant 0.22
rpoC 765291 p.Arg641Leu missense_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776979 c.1500_1501delGA frameshift_variant 1.0
mmpL5 777008 c.1473G>T synonymous_variant 1.0
mmpL5 778380 p.Pro34Gln missense_variant 0.5
rplC 801133 p.Gly109Cys missense_variant 0.29
rplC 801206 p.Arg133His missense_variant 0.2
fbiC 1303911 c.981G>A synonymous_variant 1.0
fbiC 1303965 c.1035G>A synonymous_variant 1.0
fbiC 1304165 p.Gly412Glu missense_variant 0.25
embR 1416902 p.Val149Glu missense_variant 0.4
embR 1416932 p.Ser139* stop_gained 0.4
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.67
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.8
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 1.0
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 1.0
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 1.0
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 1.0
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.75
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.75
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.75
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.5
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.5
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.5
rrs 1472666 n.821G>T non_coding_transcript_exon_variant 0.5
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.5
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 1.0
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 1.0
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.5
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 1.0
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 1.0
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.5
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.5
rrs 1472694 n.849C>A non_coding_transcript_exon_variant 0.5
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.5
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.5
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 1.0
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 1.0
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 1.0
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 1.0
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 1.0
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 1.0
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 1.0
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.7
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.45
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.45
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.42
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.42
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.42
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.38
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.46
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.31
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.38
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.31
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.38
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.38
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.69
rrs 1472993 n.1148G>T non_coding_transcript_exon_variant 0.31
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.5
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.58
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.58
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.54
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.36
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.33
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.6
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.93
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.93
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.64
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.92
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.92
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.92
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.77
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.73
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.93
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.73
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.73
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.91
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.86
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 1.0
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.75
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.67
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.67
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.4
rrl 1473714 n.57C>A non_coding_transcript_exon_variant 0.5
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 1.0
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 1.0
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 1.0
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.5
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.67
rrl 1474869 n.1212G>A non_coding_transcript_exon_variant 0.5
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 1.0
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 1.0
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 1.0
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.75
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.71
rrl 1475756 n.2101_2108delACCCGCAA non_coding_transcript_exon_variant 0.8
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.67
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.44
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.22
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.22
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.4
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.7
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.4
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.4
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.33
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.44
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.5
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.5
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.5
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.38
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.75
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.75
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.67
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.5
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.5
rrl 1476029 n.2373_2377delACCTC non_coding_transcript_exon_variant 1.0
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.67
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 1.0
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.5
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.75
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.5
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.5
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.4
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.6
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.6
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.67
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.67
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 1.0
rrl 1476167 n.2510T>G non_coding_transcript_exon_variant 0.33
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 1.0
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 1.0
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 1.0
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.75
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 1.0
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 1.0
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 1.0
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 1.0
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.8
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 1.0
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.8
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.4
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.38
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.8
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.6
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.43
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.67
fabG1 1673271 c.-169G>T upstream_gene_variant 0.67
inhA 1674391 p.Asp64Asn missense_variant 0.18
inhA 1674406 p.Glu69Lys missense_variant 0.18
inhA 1674415 p.Ala72Thr missense_variant 0.18
rpsA 1833790 c.249T>C synonymous_variant 1.0
rpsA 1833808 c.267G>C synonymous_variant 1.0
rpsA 1833811 c.270G>C synonymous_variant 1.0
rpsA 1833815 p.Thr92Gln missense_variant 1.0
rpsA 1833829 c.288A>G synonymous_variant 0.5
rpsA 1833832 c.291G>A synonymous_variant 0.75
rpsA 1833838 c.297G>C synonymous_variant 0.67
rpsA 1833856 c.315A>G synonymous_variant 0.75
rpsA 1833859 c.318C>G synonymous_variant 0.67
rpsA 1833874 c.333T>C synonymous_variant 0.4
rpsA 1833884 p.Thr115Asp missense_variant 0.33
rpsA 1833887 p.Ile116Val missense_variant 0.33
rpsA 1833893 p.Ala118Lys missense_variant 0.33
rpsA 1833896 p.Leu119Ile missense_variant 0.33
rpsA 1833907 p.Lys122Asn missense_variant 0.33
rpsA 1833912 p.Glu124Gly missense_variant 0.33
rpsA 1833915 p.Ala125Val missense_variant 0.33
rpsA 1833921 p.Lys127Thr missense_variant 0.29
rpsA 1833928 c.387G>C synonymous_variant 0.57
rpsA 1833949 c.408T>C synonymous_variant 0.2
rpsA 1833961 c.420C>G synonymous_variant 0.25
rpsA 1833970 c.429G>C synonymous_variant 0.25
rpsA 1833979 c.438T>C synonymous_variant 0.22
rpsA 1833985 c.444G>C synonymous_variant 0.22
rpsA 1833988 c.447C>G synonymous_variant 0.22
rpsA 1833991 c.450C>A synonymous_variant 0.22
rpsA 1833997 c.456G>C synonymous_variant 0.22
rpsA 1834009 c.468C>T synonymous_variant 0.27
rpsA 1834012 c.471G>C synonymous_variant 0.25
rpsA 1834015 c.474G>C synonymous_variant 0.25
rpsA 1834021 c.480C>T synonymous_variant 0.25
rpsA 1834030 c.489C>G synonymous_variant 0.25
rpsA 1834069 c.528G>C synonymous_variant 0.38
rpsA 1834093 c.552G>C synonymous_variant 0.4
rpsA 1834099 c.558C>G synonymous_variant 0.4
rpsA 1834105 c.564C>T synonymous_variant 0.4
rpsA 1834108 c.567C>A synonymous_variant 0.4
rpsA 1834114 c.573G>C synonymous_variant 0.4
rpsA 1834294 c.753G>C synonymous_variant 1.0
rpsA 1834298 p.Gln253Glu missense_variant 1.0
rpsA 1834303 c.762T>C synonymous_variant 1.0
rpsA 1834327 c.786G>C synonymous_variant 1.0
rpsA 1834340 p.Met267Leu missense_variant 1.0
rpsA 1834348 c.807T>C synonymous_variant 1.0
rpsA 1834357 c.816T>G synonymous_variant 1.0
rpsA 1834361 c.820T>C synonymous_variant 1.0
rpsA 1834366 c.825A>G synonymous_variant 1.0
rpsA 1834456 c.915T>G synonymous_variant 0.5
rpsA 1834468 c.927A>G synonymous_variant 0.4
rpsA 1834483 p.Glu314Asp missense_variant 0.5
rpsA 1834489 c.948T>C synonymous_variant 0.5
rpsA 1834498 c.957C>T synonymous_variant 0.5
rpsA 1834504 c.963G>C synonymous_variant 0.4
rpsA 1834543 c.1002C>G synonymous_variant 0.4
rpsA 1834606 c.1065C>T synonymous_variant 0.33
rpsA 1834609 c.1068T>C synonymous_variant 0.33
rpsA 1834619 c.1078T>C synonymous_variant 0.33
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.33
rpsA 1834633 c.1092A>G synonymous_variant 0.33
rpsA 1834639 c.1098T>C synonymous_variant 0.33
rpsA 1834667 p.Ala376Ser missense_variant 0.4
rpsA 1834690 c.1149T>C synonymous_variant 0.5
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918635 c.696C>A synonymous_variant 0.33
ndh 2102240 p.Arg268His missense_variant 0.5
ndh 2102595 p.Arg150Ser missense_variant 0.25
ndh 2102625 p.Ser140Pro missense_variant 0.29
katG 2154410 p.Thr568Ala missense_variant 0.5
katG 2154822 c.1290G>T synonymous_variant 0.67
katG 2155028 p.Gly362Cys missense_variant 0.4
PPE35 2167653 p.Pro987Leu missense_variant 0.29
PPE35 2167859 c.2754T>G synonymous_variant 0.5
PPE35 2168603 c.2010C>G synonymous_variant 0.25
PPE35 2168702 c.1911T>A synonymous_variant 0.4
PPE35 2168746 p.Gly623Ser missense_variant 0.29
PPE35 2168920 p.Val565Ile missense_variant 0.33
PPE35 2169398 c.1215C>T synonymous_variant 0.22
PPE35 2170174 p.Asp147Tyr missense_variant 0.18
PPE35 2170182 p.Trp144Leu missense_variant 0.22
Rv1979c 2222754 c.411G>A synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289283 c.-42A>T upstream_gene_variant 0.4
pncA 2289381 c.-140C>A upstream_gene_variant 0.67
kasA 2518894 p.Lys260Asn missense_variant 0.4
kasA 2519158 c.1044C>A synonymous_variant 0.25
eis 2714569 p.Ala255Gly missense_variant 0.33
ahpC 2726264 c.72C>A synonymous_variant 0.29
folC 2746581 p.Glu340Lys missense_variant 0.33
folC 2747431 c.168G>T synonymous_variant 0.33
pepQ 2859762 c.657G>A synonymous_variant 0.67
pepQ 2859863 p.Asp186Asn missense_variant 0.33
pepQ 2859879 p.Met180Ile missense_variant 0.33
pepQ 2860090 p.Leu110* stop_gained 0.33
Rv2752c 3065767 c.424delG frameshift_variant 0.67
thyX 3067618 p.Pro110Ser missense_variant 0.4
thyX 3067628 p.Gln106Pro missense_variant 0.4
thyX 3067631 c.315C>T synonymous_variant 0.4
thyX 3067875 p.Pro24His missense_variant 0.18
thyX 3067882 p.Asp22Tyr missense_variant 0.17
thyA 3074273 p.Ser67Thr missense_variant 0.4
thyA 3074374 p.Gln33Leu missense_variant 0.33
thyA 3074564 c.-93G>T upstream_gene_variant 0.18
thyA 3074654 c.-183T>G upstream_gene_variant 0.29
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087078 p.His87Asn missense_variant 0.4
ald 3087489 p.Glu224Lys missense_variant 1.0
ald 3087846 p.Leu343Phe missense_variant 0.67
fbiD 3339226 p.Asn37Tyr missense_variant 0.25
Rv3083 3449721 c.1218G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474899 p.Gly298Val missense_variant 0.4
fprA 3475017 p.Gln337His missense_variant 0.4
whiB7 3568777 c.-98C>A upstream_gene_variant 1.0
Rv3236c 3612062 p.Ala352Phe missense_variant 0.25
Rv3236c 3612067 c.1050G>T synonymous_variant 0.25
Rv3236c 3613031 p.Ala29Val missense_variant 0.18
Rv3236c 3613054 c.63G>C synonymous_variant 0.18
Rv3236c 3613179 c.-63T>C upstream_gene_variant 0.33
fbiB 3641692 p.Val53Glu missense_variant 0.22
fbiB 3641718 p.Pro62Thr missense_variant 0.5
fbiB 3641867 c.333C>A synonymous_variant 0.29
fbiB 3642324 p.Arg264Ser missense_variant 0.22
fbiB 3642334 p.Ser267Asn missense_variant 0.25
fbiB 3642852 p.Pro440Ser missense_variant 0.22
alr 3840820 p.Asp201Asn missense_variant 1.0
alr 3841102 p.Ala107Thr missense_variant 0.2
alr 3841112 p.Asp103Glu missense_variant 0.2
alr 3841191 p.Val77Asp missense_variant 0.29
ddn 3986942 c.99C>T synonymous_variant 0.4
ddn 3986996 c.153C>A synonymous_variant 0.25
clpC1 4038295 p.Val804Leu missense_variant 0.67
clpC1 4038297 p.Asp803Val missense_variant 0.67
clpC1 4038331 p.Glu792* stop_gained 0.67
clpC1 4038860 c.1845G>C synonymous_variant 0.22
clpC1 4038878 c.1827A>G synonymous_variant 0.29
clpC1 4038890 c.1815G>A synonymous_variant 0.38
clpC1 4038911 c.1794G>T synonymous_variant 0.6
clpC1 4038917 c.1788C>T synonymous_variant 0.6
clpC1 4038923 c.1782A>G synonymous_variant 0.6
clpC1 4038926 c.1779G>T synonymous_variant 0.6
clpC1 4038941 c.1764G>C synonymous_variant 0.6
clpC1 4038944 c.1761C>T synonymous_variant 0.6
clpC1 4038953 c.1752A>G synonymous_variant 0.6
clpC1 4038956 c.1749T>C synonymous_variant 0.6
clpC1 4038965 c.1740T>C synonymous_variant 0.67
clpC1 4038971 c.1734T>C synonymous_variant 0.67
clpC1 4038974 c.1731T>C synonymous_variant 0.67
clpC1 4038980 c.1725C>T synonymous_variant 0.56
clpC1 4038986 p.Asp573Glu missense_variant 0.44
clpC1 4038989 c.1716T>C synonymous_variant 0.5
clpC1 4038997 c.1708T>C synonymous_variant 0.55
clpC1 4039004 c.1701C>G synonymous_variant 0.5
clpC1 4039019 c.1686G>C synonymous_variant 0.45
clpC1 4039022 c.1683A>G synonymous_variant 0.45
clpC1 4039073 c.1632C>T synonymous_variant 0.57
clpC1 4039079 c.1626C>G synonymous_variant 0.57
clpC1 4039082 c.1623C>T synonymous_variant 0.57
clpC1 4039085 c.1620A>G synonymous_variant 0.5
clpC1 4039091 c.1614G>T synonymous_variant 0.5
clpC1 4039097 c.1608G>T synonymous_variant 0.5
clpC1 4039106 c.1599G>T synonymous_variant 0.5
clpC1 4039118 c.1587C>G synonymous_variant 0.5
clpC1 4039121 c.1584T>G synonymous_variant 0.4
clpC1 4039124 c.1581C>G synonymous_variant 0.4
clpC1 4039142 c.1563A>G synonymous_variant 0.4
clpC1 4039145 c.1560G>C synonymous_variant 0.5
clpC1 4039169 p.Glu512Asp missense_variant 0.67
clpC1 4039172 c.1533A>G synonymous_variant 0.67
clpC1 4039178 c.1527G>C synonymous_variant 0.67
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.5
clpC1 4039187 c.1518G>T synonymous_variant 0.5
clpC1 4039199 p.Ala502Glu missense_variant 0.5
clpC1 4039324 p.Arg461Cys missense_variant 0.67
clpC1 4039487 c.1218G>C synonymous_variant 0.17
clpC1 4039499 c.1206G>C synonymous_variant 0.17
clpC1 4039517 c.1188C>G synonymous_variant 0.15
clpC1 4039544 c.1161C>T synonymous_variant 0.14
clpC1 4039553 c.1152C>G synonymous_variant 0.14
clpC1 4039559 c.1146C>T synonymous_variant 0.17
clpC1 4039562 c.1143C>G synonymous_variant 0.17
clpC1 4039565 c.1140G>C synonymous_variant 0.17
clpC1 4039570 p.Met379Leu missense_variant 0.17
clpC1 4039574 p.Ala377Gly missense_variant 0.17
clpC1 4039577 c.1128T>C synonymous_variant 0.17
clpC1 4039586 c.1119G>C synonymous_variant 0.25
clpC1 4039589 c.1116G>C synonymous_variant 0.25
clpC1 4039592 c.1113G>C synonymous_variant 0.25
clpC1 4039603 p.Ala368Ser missense_variant 0.25
clpC1 4039613 c.1092C>T synonymous_variant 0.22
clpC1 4039616 c.1089G>C synonymous_variant 0.22
clpC1 4039622 c.1083C>T synonymous_variant 0.25
embC 4240511 p.Ser217Cys missense_variant 0.15
embC 4240648 c.786C>T synonymous_variant 0.38
embC 4241086 c.1224G>A synonymous_variant 0.5
embC 4241464 c.1602C>A synonymous_variant 0.22
embC 4241557 c.1695C>T synonymous_variant 0.33
embC 4242422 p.Trp854Gly missense_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244220 c.988C>T synonymous_variant 0.17
embA 4245635 p.Lys801Asn missense_variant 0.5
embB 4246724 p.Leu71Met missense_variant 0.2
embB 4246731 p.Ser73Leu missense_variant 0.2
embB 4246822 c.309C>A synonymous_variant 0.22
embB 4246885 p.Asp124Glu missense_variant 0.22
embB 4247097 p.Pro195His missense_variant 0.22
embB 4247276 p.Pro255Ser missense_variant 0.4
embB 4248157 c.1644A>T synonymous_variant 0.2
embB 4248321 p.Gly603Val missense_variant 0.2
embB 4248719 p.Gly736Ser missense_variant 0.33
embB 4249408 c.2895G>A synonymous_variant 1.0
embB 4249724 p.Val1071Phe missense_variant 0.67
aftB 4266964 p.Pro625Thr missense_variant 0.4
aftB 4268883 c.-47G>T upstream_gene_variant 0.25
aftB 4268898 c.-62G>T upstream_gene_variant 0.29
ethA 4327034 p.Tyr147Phe missense_variant 0.33
whiB6 4338199 c.321_322delCG frameshift_variant 0.5
whiB6 4338295 p.Trp76* stop_gained 0.67
gid 4407798 c.405G>T synonymous_variant 1.0