TB-Profiler result

Run: ERR2513450
Summary

Run ID: ERR2513450

Sample name:

Date: 31-03-2023 19:41:11

Number of reads: 1746185

Percentage reads mapped: 94.4

Strain: lineage1.2.1.2.1

Drug-resistance: Other

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 1.0
lineage1.2.1 Indo-Oceanic EAI2 RD239 1.0
lineage1.2.1.2 Indo-Oceanic NA RD239 1.0
lineage1.2.1.2.1 Indo-Oceanic NA RD239 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.74 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9260 c.1959G>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575368 c.21T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763531 c.162G>C synonymous_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 1.0
atpE 1460907 c.-138T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.12
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.14
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.2
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.31
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.17
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.37
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.15
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.26
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.15
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.6
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.55
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.55
rrs 1472498 n.653C>A non_coding_transcript_exon_variant 0.33
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.38
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.38
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.38
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.4
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.5
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.5
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.5
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.46
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.46
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.4
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.33
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.55
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.64
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.64
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.58
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.76
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.68
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.68
rrs 1472665 n.820G>A non_coding_transcript_exon_variant 0.11
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.22
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.67
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.54
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.77
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.77
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.73
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.73
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.67
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.65
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.65
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.5
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.5
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.33
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.4
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.2
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.56
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.56
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.5
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.62
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.44
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.44
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.85
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.83
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.83
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.85
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.53
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.53
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.72
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.58
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.47
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.11
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.37
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.53
rrs 1473109 n.1264T>C non_coding_transcript_exon_variant 0.15
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.6
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.6
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.6
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.53
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.35
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.41
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.18
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.23
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.24
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.25
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.32
rrs 1473201 n.1356A>C non_coding_transcript_exon_variant 0.1
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.25
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.21
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.21
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.29
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.21
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.19
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.27
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.21
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.25
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.25
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.21
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.14
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.21
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.21
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.21
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.23
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.22
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.22
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.22
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.22
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.2
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.2
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.2
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.25
rrl 1475995 n.2338G>C non_coding_transcript_exon_variant 0.25
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.25
rrl 1475998 n.2341C>G non_coding_transcript_exon_variant 0.25
rrl 1476000 n.2343G>A non_coding_transcript_exon_variant 0.25
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.25
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.25
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.25
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.25
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.25
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.14
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.39
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.38
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.16
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.13
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.4
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.32
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.19
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.26
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.19
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.23
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.27
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.22
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.27
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.27
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.23
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.19
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.2
inhA 1674162 c.-40C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2519048 p.Gly312Ser missense_variant 1.0
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339417 c.300A>G synonymous_variant 1.0
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
whiB7 3568488 c.191delG frameshift_variant 1.0
fbiB 3640557 c.-978T>C upstream_gene_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243580 c.348G>A synonymous_variant 1.0
embA 4244420 c.1188G>C synonymous_variant 1.0
embA 4245969 p.Pro913Ser missense_variant 1.0
embB 4247578 c.1065G>A synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ubiA 4269864 c.-32delG upstream_gene_variant 1.0
whiB6 4338361 p.Arg54Gln missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0