TB-Profiler result

Run: ERR2514535
Summary

Run ID: ERR2514535

Sample name:

Date: 31-03-2023 20:23:55

Number of reads: 1345486

Percentage reads mapped: 95.3

Strain: lineage3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8172 p.Val291Phe missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 760361 c.555T>C synonymous_variant 0.17
rpoB 760376 p.Asp190Glu missense_variant 0.14
rpoB 760380 p.Thr192Leu missense_variant 0.14
rpoB 760406 c.600G>C synonymous_variant 0.14
rpoB 760424 c.618C>G synonymous_variant 0.14
rpoB 760430 c.624T>C synonymous_variant 0.12
rpoB 760484 c.678A>G synonymous_variant 0.13
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766573 c.3204T>C synonymous_variant 0.12
rpoC 766582 c.3213C>G synonymous_variant 0.12
rpoC 766583 p.Gly1072Ser missense_variant 0.12
rpoC 766933 c.3564A>G synonymous_variant 0.16
rpoC 766942 c.3573C>T synonymous_variant 0.14
rpoC 766945 c.3576A>G synonymous_variant 0.14
rpoC 766963 c.3594T>C synonymous_variant 0.14
rpoC 766972 c.3603G>C synonymous_variant 0.14
rpoC 766996 c.3627C>T synonymous_variant 0.14
rpoC 767035 c.3666G>C synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304817 c.1887T>C synonymous_variant 0.13
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.21
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.23
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.21
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.14
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.25
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.25
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29
rrl 1475739 n.2082A>G non_coding_transcript_exon_variant 0.33
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.22
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.22
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.12
inhA 1674243 c.42A>G synonymous_variant 0.14
inhA 1674279 c.78A>C synonymous_variant 0.18
inhA 1674280 p.Arg27Lys missense_variant 0.19
inhA 1674284 p.Val28Ala missense_variant 0.19
inhA 1674301 c.102_103delCC frameshift_variant 0.16
inhA 1674331 c.130C>T synonymous_variant 0.14
inhA 1674603 c.402G>A synonymous_variant 0.12
inhA 1674627 c.426T>G synonymous_variant 0.14
inhA 1674639 c.438C>G synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2517980 c.-135C>T upstream_gene_variant 0.14
kasA 2518594 c.480C>G synonymous_variant 0.12
kasA 2518597 c.483C>G synonymous_variant 0.13
kasA 2518609 p.Met165Ile missense_variant 0.12
kasA 2518672 c.558G>C synonymous_variant 0.12
kasA 2518678 c.564C>T synonymous_variant 0.12
kasA 2518684 c.570C>G synonymous_variant 0.12
kasA 2518783 c.669T>C synonymous_variant 0.13
kasA 2518789 c.675G>C synonymous_variant 0.13
kasA 2518792 c.678C>G synonymous_variant 0.13
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
Rv2752c 3066197 c.-6C>T upstream_gene_variant 0.95
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3877776 c.732T>C synonymous_variant 0.14
embC 4240069 c.207T>C synonymous_variant 1.0
embC 4240780 c.918T>C synonymous_variant 0.13
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408163 p.Pro14Ser missense_variant 1.0