Run ID: ERR2707074
Sample name:
Date: 19-10-2023 12:09:29
Number of reads: 2882009
Percentage reads mapped: 99.65
Strain: lineage4.6.1.2
Drug-resistance: RR-TB
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | R | rpoB p.Ser450Leu (1.00) |
Isoniazid | ||
Ethambutol | R | embA c.-11C>A (1.00), embB p.Met306Ile (0.35) |
Pyrazinamide | ||
Streptomycin | R | rrs n.905C>G (0.64) |
Fluoroquinolones | ||
Moxifloxacin | ||
Ofloxacin | ||
Levofloxacin | ||
Ciprofloxacin | ||
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | ||
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.6 | Euro-American | T;LAM | None | 1.0 |
lineage4.6.1 | Euro-American (Uganda) | T2 | RD724 | 1.0 |
lineage4.6.1.2 | Euro-American | T2 | RD724 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
rrs | 1472750 | n.905C>G | non_coding_transcript_exon_variant | 0.64 | streptomycin |
embA | 4243222 | c.-11C>A | upstream_gene_variant | 1.0 | ethambutol |
embB | 4247431 | p.Met306Ile | missense_variant | 0.35 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7539 | p.Thr80Ala | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
rpoB | 762127 | p.Val774Glu | missense_variant | 0.33 |
rpoC | 764810 | p.Pro481Thr | missense_variant | 1.0 |
rpoC | 765862 | p.Phe831Leu | missense_variant | 0.59 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
embR | 1416410 | p.Leu313Arg | missense_variant | 0.99 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2155249 | p.Pro288His | missense_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
pncA | 2289010 | p.Gly78Arg | missense_variant | 1.0 |
Rv2752c | 3065920 | p.Pro91Leu | missense_variant | 1.0 |
Rv2752c | 3066211 | c.-20A>G | upstream_gene_variant | 0.33 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embA | 4245055 | p.Thr608Asn | missense_variant | 1.0 |
ubiA | 4269148 | p.Val229Ala | missense_variant | 0.68 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |