TB-Profiler result

Run: ERR3275196
Summary

Run ID: ERR3275196

Sample name:

Date: 2024-10-04T05:14:14.354362

Number of reads: 2450109

Percentage reads mapped: 97.66

Median coverage: 43.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.96
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.39 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.24 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
dnaA 1098 c.1098A>G synonymous_variant 0.17 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.18 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.21 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.23 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.24 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.24 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.23 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.24 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.28 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.28 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.3 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.29 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.25 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.21 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.22 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.21 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.2 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.21 isoniazid
gyrB 6148 c.909C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7710 c.409T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7884 p.Arg195Gly missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7892 c.591G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8735 c.1434C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8747 c.1446A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491121 c.339A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491137 p.Glu119Gln missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Glu missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491166 c.384G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491196 c.414A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491295 c.513C>G synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491319 c.537G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491331 c.549G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491472 c.690A>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491502 c.720G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491509 c.727T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491583 c.801G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 574625 c.-723C>G upstream_gene_variant 0.24 isoniazid
ethionamide
mshA 574650 c.-698A>C upstream_gene_variant 0.21 isoniazid
ethionamide
mshA 574655 c.-693C>G upstream_gene_variant 0.23 isoniazid
ethionamide
mshA 574664 c.-684G>C upstream_gene_variant 0.2 isoniazid
ethionamide
mshA 574671 c.-677_-675delGCAinsCTG upstream_gene_variant 0.19 isoniazid
ethionamide
mshA 574676 c.-672G>C upstream_gene_variant 0.19 isoniazid
ethionamide
mshA 574683 c.-665T>C upstream_gene_variant 0.19 isoniazid Uncertain significance
ethionamide
mshA 574688 c.-660G>C upstream_gene_variant 0.2 isoniazid Uncertain significance
ethionamide Uncertain significance
mshA 574694 c.-654C>G upstream_gene_variant 0.18 isoniazid
ethionamide
mshA 574700 c.-648C>G upstream_gene_variant 0.17 isoniazid
ethionamide
mshA 574712 c.-636A>G upstream_gene_variant 0.16 isoniazid
ethionamide
mshA 575279 c.-69C>G upstream_gene_variant 1.0 isoniazid
ethionamide
mshA 575561 p.Met72Val missense_variant 0.16 isoniazid
ethionamide
mshA 575569 c.222A>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575571 p.Ser75Thr missense_variant 0.17 isoniazid
ethionamide
mshA 575575 c.228G>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575587 c.240C>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575590 c.243T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575593 c.246G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575623 c.276C>G synonymous_variant 0.25 isoniazid
ethionamide
mshA 575629 c.282A>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575635 c.288A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ethionamide
mshA 575638 c.291T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575648 p.Val101Gln missense_variant 0.22 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.33 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.38 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.4 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.4 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.46 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.45 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.46 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.49 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.46 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.48 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 619502 c.-389_-388delAAinsCG upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619507 c.-384A>G upstream_gene_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 619558 c.-333G>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620257 p.Ile123Val missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Ile missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620275 c.385C>T synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620569 p.Gly227Arg missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620589 c.699G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620598 c.708C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620622 c.732G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 0.71 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
Rv0565c 656860 p.Glu204Ala missense_variant 0.18 ethionamide
Rv0565c 656865 c.606G>C synonymous_variant 0.18 ethionamide
Rv0565c 656872 p.Thr200Ser missense_variant 0.19 ethionamide
Rv0565c 656880 c.591C>G synonymous_variant 0.19 ethionamide
Rv0565c 656883 p.Ile196Leu missense_variant 0.21 ethionamide Uncertain significance
Rv0565c 656889 c.582A>G synonymous_variant 0.21 ethionamide
Rv0565c 656901 c.570C>G synonymous_variant 0.22 ethionamide
Rv0565c 656922 p.Ile183Val missense_variant 0.22 ethionamide
Rv0565c 656934 c.537C>G synonymous_variant 0.22 ethionamide
Rv0565c 656943 c.528G>C synonymous_variant 0.22 ethionamide
Rv0565c 656946 c.525T>C synonymous_variant 0.23 ethionamide
Rv0565c 656952 c.519A>C synonymous_variant 0.2 ethionamide Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 0.98 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.94 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.22 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.21 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.19 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.2 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.24 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.24 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.2 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.2 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.19 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.19 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.16 ethionamide
Rv0565c 657357 c.114C>G synonymous_variant 0.17 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.19 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.2 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.16 ethionamide
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.24 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.27 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.26 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.28 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.26 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.27 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.27 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.26 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.24 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.28 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.3 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.25 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.29 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.3 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734778 c.525G>C synonymous_variant 0.33 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.33 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.35 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.32 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.36 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.43 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.41 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.41 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.39 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.39 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.36 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.33 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.32 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.26 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.18 rifampicin
rpoB 760088 c.282C>G synonymous_variant 0.24 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.18 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.25 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.38 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.41 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.44 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.43 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.4 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.41 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.38 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760514 c.708C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.28 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.35 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.45 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.34 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.31 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.31 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.38 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.33 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.32 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.3 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.28 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.28 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.31 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.34 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.3 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.29 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.23 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.27 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.31 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.31 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.31 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.35 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.35 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.38 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.41 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.32 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.31 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.38 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.36 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.44 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.45 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.49 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761285 c.1479G>A synonymous_variant 0.53 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>A synonymous_variant 0.33 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.26 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.2 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.19 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.19 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.21 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.2 rifampicin
rpoB 761452 p.Val549Ala missense_variant 0.19 rifampicin
rpoB 761457 p.Pro551Ala missense_variant 0.19 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.21 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.32 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.38 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.33 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.35 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.31 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.28 rifampicin
rpoB 761714 c.1908C>G synonymous_variant 0.24 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.18 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.24 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.24 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.25 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.26 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.26 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.27 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.3 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.26 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.24 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762027 c.2221_2223delCTCinsTTG synonymous_variant 0.24 rifampicin
rpoB 762032 c.2226C>G synonymous_variant 0.25 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.25 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.28 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.26 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.24 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.31 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.34 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.31 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.31 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.3 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.26 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.23 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.23 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.5 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.53 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.37 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.18 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.2 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.22 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.22 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>C upstream_gene_variant 0.24 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.22 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763268 c.3462C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.2 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.32 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.39 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.44 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.37 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.42 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.32 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.29 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.21 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.2 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.24 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.3 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.3 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.3 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.33 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.36 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.36 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.36 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.37 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.37 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.38 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.3 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.29 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.3 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.27 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.33 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.36 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.33 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.35 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.35 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.27 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.26 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.26 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.28 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.25 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.25 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.25 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.24 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.29 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.29 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.36 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.28 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.17 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.28 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.43 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.42 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.47 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.36 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.31 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.29 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.18 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>G synonymous_variant 0.18 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765349 c.1980T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.31 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.39 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.36 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.38 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.4 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.4 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765535 c.2166C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.36 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.4 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.38 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.36 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.37 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.31 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.27 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.34 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.36 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.32 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.39 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.39 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.29 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.27 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.24 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.25 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.28 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.3 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.25 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.27 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.26 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.2 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.37 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.39 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.38 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.38 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.39 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.38 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.34 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.31 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.28 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.19 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.19 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.19 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.19 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.26 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.26 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.24 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.21 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.37 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.36 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.35 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.31 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.32 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.32 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.35 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.41 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.23 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.31 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.26 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.33 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775966 p.Ala839Ser missense_variant 0.24 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.27 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.22 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 776008 p.His825Tyr missense_variant 0.18 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpL5 776452 p.Gly677Ser missense_variant 1.0 bedaquiline
clofazimine
mmpL5 777158 c.1323C>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777164 c.1317C>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 777173 c.1308C>G synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.2 bedaquiline
clofazimine
mmpL5 777179 c.1302G>C synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777188 c.1293T>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777203 c.1278G>C synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777206 c.1275A>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777214 p.Ala423Thr missense_variant 0.18 bedaquiline
clofazimine
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 p.Ser17Gly missense_variant 0.31 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.47 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.48 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.48 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.49 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.52 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.48 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.44 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.41 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.39 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.37 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.3 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.32 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.3 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.31 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.31 streptomycin Uncertain significance
rplC 800618 c.-191T>C upstream_gene_variant 0.16 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.26 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.31 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.33 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.29 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.26 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.28 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.26 linezolid
rplC 800814 c.6A>G synonymous_variant 0.23 linezolid
rplC 800817 c.9A>T synonymous_variant 0.27 linezolid
rplC 800844 c.36T>C synonymous_variant 0.26 linezolid
rplC 800865 c.57A>G synonymous_variant 0.27 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.27 linezolid
rplC 800874 c.66A>G synonymous_variant 0.26 linezolid
rplC 800877 c.69A>C synonymous_variant 0.24 linezolid
rplC 800880 c.72A>G synonymous_variant 0.23 linezolid
rplC 800889 c.81C>G synonymous_variant 0.27 linezolid
rplC 800907 c.99C>G synonymous_variant 0.32 linezolid
rplC 800916 c.108A>G synonymous_variant 0.33 linezolid
rplC 800937 c.129A>G synonymous_variant 0.24 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.22 linezolid
rplC 800946 c.138T>C synonymous_variant 0.19 linezolid
rplC 800949 c.141T>C synonymous_variant 0.19 linezolid
rplC 800955 c.147C>G synonymous_variant 0.21 linezolid
rplC 800967 c.159C>G synonymous_variant 0.18 linezolid
rplC 800970 c.162T>C synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.15 linezolid
rplC 801171 c.363A>G synonymous_variant 0.22 linezolid
rplC 801174 c.366T>C synonymous_variant 0.25 linezolid
rplC 801183 c.375C>A synonymous_variant 0.33 linezolid
rplC 801222 c.414T>C synonymous_variant 0.32 linezolid
rplC 801228 c.420T>C synonymous_variant 0.31 linezolid
rplC 801246 c.438C>G synonymous_variant 0.28 linezolid
rplC 801249 c.441T>G synonymous_variant 0.28 linezolid
rplC 801255 c.447C>T synonymous_variant 0.24 linezolid
rplC 801267 c.459A>C synonymous_variant 0.22 linezolid
rplC 801270 c.462T>C synonymous_variant 0.22 linezolid
rplC 801276 c.468G>C synonymous_variant 0.22 linezolid
rplC 801279 c.471G>C synonymous_variant 0.2 linezolid
rplC 801282 c.474G>C synonymous_variant 0.21 linezolid
rplC 801301 c.493C>A synonymous_variant 0.23 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801396 c.588T>C synonymous_variant 0.16 linezolid
rplC 801402 c.594T>C synonymous_variant 0.16 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303476 c.546G>C synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303560 c.630G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303701 c.771C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303881 c.951G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304046 c.1116C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304080 p.Ala384Ser missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304091 p.Asp387Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304092 p.Met388Leu missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304097 c.1167G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304934 c.2004C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304961 c.2031C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304991 c.2061G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304995 c.2065T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305297 c.2367G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305300 c.2370A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305303 c.2373T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305306 c.2376A>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305311 p.Arg794Gln missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305331 p.Glu801Asn missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305336 c.2406T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1305381 c.2451G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
sigE 1364784 c.372C>G synonymous_variant 0.18 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.19 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.2 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.19 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.27 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.31 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.32 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.29 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.3 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.3 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.32 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.35 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.25 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.19 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1461107 c.63C>G synonymous_variant 0.18 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.21 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.29 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.34 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.33 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.33 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.32 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.29 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.29 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.25 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673580 c.-622T>C upstream_gene_variant 0.24 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673596 c.-606_-604delAAGinsGAC upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673610 c.-592C>T upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673616 c.-586A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673679 c.-523T>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1674379 c.178C>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.36 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.42 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.42 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.49 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.34 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.31 isoniazid
ethionamide
inhA 1674909 c.708G>C synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674915 c.714C>G synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674942 c.741T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674993 c.792G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674994 p.His265Ser missense_variant 0.18 isoniazid
ethionamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.2 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.29 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.26 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.28 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.41 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.33 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.37 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.35 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.37 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.34 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.4 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.38 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.35 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.35 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.34 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.38 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.39 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.42 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.36 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.38 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.38 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.26 linezolid
tsnR 1853484 c.-122_-121delAGinsGC upstream_gene_variant 0.24 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.24 linezolid
tsnR 1853498 c.-108G>C upstream_gene_variant 0.25 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064907 c.-179G>A upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064939 c.-211C>T upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102009 p.Ser345Asn missense_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102020 c.1023A>G synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2102023 c.1020G>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2102026 c.1017G>C synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102050 c.993T>C synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2102053 c.990G>C synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102059 c.984T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2102065 c.978G>C synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102068 c.975T>C synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2102212 c.831G>C synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2102218 c.825C>G synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102233 c.810G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102305 c.738T>C synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102317 c.726A>G synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102323 c.720C>G synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102545 c.498G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2102559 p.Ser162Arg missense_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102566 c.477A>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2102572 c.471A>G synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2102581 c.462T>G synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2102589 c.454T>C synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102590 c.453A>C synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102593 c.450C>G synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102596 c.447C>G synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102599 c.444T>C synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102604 p.Leu147Val missense_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2102608 c.433_435delTTGinsCTC synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102635 c.408C>G synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2102638 c.405A>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2102644 c.399A>G synonymous_variant 0.18 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2154816 c.1296C>G synonymous_variant 1.0 isoniazid
katG 2155677 c.435C>G synonymous_variant 0.23 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.24 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.23 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.21 isoniazid
katG 2155701 c.411C>T synonymous_variant 0.21 isoniazid Not assoc w R - Interim
katG 2155704 c.408C>G synonymous_variant 0.21 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.21 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.21 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.3 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.2 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.19 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.23 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.25 isoniazid
kasA 2518222 c.108G>A synonymous_variant 0.23 isoniazid
kasA 2518223 c.109_111delTTGinsCTC synonymous_variant 0.23 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.25 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.21 isoniazid
kasA 2518261 p.Glu49Asp missense_variant 0.19 isoniazid
kasA 2518263 p.Phe50Tyr missense_variant 0.18 isoniazid
kasA 2518265 p.Val51Ile missense_variant 0.18 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.19 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.32 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.32 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.33 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.32 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.38 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.37 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.38 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.38 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.43 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.39 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.35 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.4 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.34 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.28 isoniazid
kasA 2518690 c.576C>T synonymous_variant 0.29 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.29 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.29 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.27 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.25 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.26 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.28 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.33 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.29 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.31 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.34 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.35 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.33 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.27 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.2 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.2 isoniazid
kasA 2519125 c.1011C>T synonymous_variant 0.19 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.22 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.22 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.21 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.23 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.23 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.21 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.18 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726681 c.489A>G synonymous_variant 0.17 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.16 isoniazid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.21 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.34 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.29 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.29 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.32 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064962 c.1230C>A synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064980 c.1212C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3064995 c.1197C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064998 c.1194A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065018 p.Asn392His missense_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065028 c.1164G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065031 c.1161G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065040 c.1152C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065082 c.1110G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066087 c.105A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066118 p.Asn25Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066765 c.-574G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066798 c.-607G>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066822 c.-631T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066867 c.-676T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067355 c.591A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067761 p.Arg62Gln missense_variant 0.16 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.23 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067894 c.52T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.3 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.29 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074088 c.384C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448838 p.Arg112Pro missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3612685 c.432C>T synonymous_variant 0.17 pyrazinamide
Rv3236c 3612694 p.Arg141His missense_variant 0.18 pyrazinamide Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 0.97 pyrazinamide Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624094 c.817A>C synonymous_variant 0.26 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.27 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.27 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624172 p.Val247Ile missense_variant 0.2 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624188 c.723G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624191 c.720C>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624194 c.717C>A synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624200 c.711A>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624209 c.702A>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624371 c.540T>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624389 c.522C>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624401 c.510C>T synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624407 c.504C>G synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624425 p.Glu162Ala missense_variant 0.26 rifampicin
bedaquiline
lpqB 3624428 c.483A>G synonymous_variant 0.28 rifampicin
bedaquiline
lpqB 3624452 c.459T>G synonymous_variant 0.3 rifampicin
bedaquiline
lpqB 3624464 c.447A>G synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624470 c.441T>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624476 c.435C>G synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624482 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624485 p.Asp142Gly missense_variant 0.24 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624491 c.420G>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624680 c.231T>G synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.23 rifampicin
bedaquiline
lpqB 3624701 c.210T>C synonymous_variant 0.28 rifampicin
bedaquiline
lpqB 3624713 c.198C>T synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.28 rifampicin
bedaquiline
lpqB 3624728 c.183C>T synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624760 c.151C>T synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624770 c.141T>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3625045 c.-135C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625069 c.-159T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625072 c.-162G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625075 c.-165G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625087 p.Ala509Ser missense_variant 0.19 rifampicin
bedaquiline
mtrB 3625093 p.Glu507Asp missense_variant 0.19 rifampicin
bedaquiline
lpqB 3625099 c.-189C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625513 c.-603G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625525 c.-615G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.35 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.41 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.49 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.47 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.47 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.48 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.39 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.34 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.37 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625888 c.-978G>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626711 c.-98T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627191 c.-578G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627323 c.-712_-710delTTGinsCTC upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.18 rifampicin
bedaquiline
mtrB 3627360 c.-747G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627373 c.-760G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627377 c.-764G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
fbiB 3642581 c.1047A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiB 3642593 c.1059G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642602 c.1068A>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642605 c.1071A>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642659 c.1125C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642662 c.1128C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642668 c.1134A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642677 c.1143A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3642680 c.1146A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3642684 c.1150T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiB 3642694 p.Ala387Gly missense_variant 0.17 pretomanid
delamanid
clofazimine
rpoA 3877503 c.1005G>C synonymous_variant 0.18 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.21 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.24 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.31 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.34 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.43 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.28 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.23 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.29 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.31 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.35 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.33 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.35 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.35 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.27 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.27 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.3 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.28 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.29 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.31 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.33 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.32 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.3 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.3 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.28 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.31 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.25 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.27 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.28 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.34 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.4 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.43 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.44 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.33 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.29 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.25 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.26 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.24 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.26 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.27 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.3 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.31 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.32 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.31 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.28 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.26 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.24 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.31 pretomanid
delamanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.29 pretomanid
delamanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.27 pretomanid
delamanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.28 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.26 pretomanid
delamanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.26 pretomanid
delamanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.23 pretomanid
delamanid
clpC1 4038271 p.Pro812Ala missense_variant 0.32 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.33 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.42 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.37 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038434 c.2271G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.28 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.36 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.4 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.39 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.42 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.45 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.44 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.42 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.41 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.41 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.48 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039016 c.1689C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.31 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.27 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.27 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.21 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.29 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.37 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.42 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.33 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.34 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.33 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040210 c.495G>A synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.35 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.36 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.19 pyrazinamide
panD 4044635 c.-354G>C upstream_gene_variant 0.33 pyrazinamide
panD 4044644 c.-363A>G upstream_gene_variant 0.35 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.37 pyrazinamide
panD 4044656 c.-375G>T upstream_gene_variant 0.29 pyrazinamide
panD 4044662 c.-381C>G upstream_gene_variant 0.27 pyrazinamide
panD 4044672 c.-392_-391delGCinsCA upstream_gene_variant 0.26 pyrazinamide
panD 4044674 c.-393C>G upstream_gene_variant 0.26 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.28 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.28 pyrazinamide
panD 4044688 c.-407T>C upstream_gene_variant 0.3 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.31 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.31 pyrazinamide
panD 4044704 c.-423G>T upstream_gene_variant 0.33 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.31 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.17 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.17 pyrazinamide
panD 4044780 c.-500_-499delCTinsTG upstream_gene_variant 0.17 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044954 c.-673C>T upstream_gene_variant 0.24 pyrazinamide
panD 4044965 c.-684T>C upstream_gene_variant 0.28 pyrazinamide
panD 4044974 c.-693C>G upstream_gene_variant 0.27 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.28 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.28 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.27 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.3 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.29 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.29 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.29 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.24 pyrazinamide
panD 4045063 c.-782T>C upstream_gene_variant 0.19 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.16 pyrazinamide
glpK 4138518 p.Glu413Ala missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138535 c.1221T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138538 c.1218C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138547 c.1209C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138664 c.1092G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138667 c.1089G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.571_572dupGG frameshift_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139575 p.Val61Ile missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 p.Ala53Thr missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240204 c.342T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4240210 c.348C>G synonymous_variant 0.18 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.16 ethambutol
embC 4240229 p.Leu123Ile missense_variant 0.16 ethambutol
embC 4240232 p.Gln124Val missense_variant 0.17 ethambutol
embC 4240633 p.Met257Ile missense_variant 0.16 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.21 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.26 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.25 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.21 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.2 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.19 ethambutol
embC 4240690 c.828G>A synonymous_variant 0.18 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.19 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.23 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240789 c.927T>C synonymous_variant 0.19 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.34 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.34 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.37 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.43 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.41 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.45 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.44 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.46 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.43 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.4 ethambutol
embC 4240919 c.1057_1059delCTCinsTTG synonymous_variant 0.39 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.36 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.33 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.33 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.33 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.28 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.3 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.33 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.41 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.43 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.44 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.47 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.42 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.37 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.36 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.32 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.3 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.27 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.24 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.18 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.19 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.2 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.34 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.4 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.36 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.33 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.34 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.27 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.27 ethambutol
embA 4245215 c.1983A>G synonymous_variant 0.26 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.21 ethambutol
embB 4245599 c.-915A>G upstream_gene_variant 0.23 ethambutol
embB 4245620 c.-894T>C upstream_gene_variant 0.17 ethambutol
embB 4245626 c.-888G>C upstream_gene_variant 0.17 ethambutol
embA 4245643 p.Ala804Val missense_variant 0.25 ethambutol
embA 4245648 p.Ile806Tyr missense_variant 0.24 ethambutol
embA 4245652 p.Thr807Ser missense_variant 0.23 ethambutol
embB 4245659 c.-855C>G upstream_gene_variant 0.24 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4245677 c.-837G>C upstream_gene_variant 0.24 ethambutol
embB 4245683 c.-831C>G upstream_gene_variant 0.22 ethambutol
embB 4245689 c.-825C>G upstream_gene_variant 0.2 ethambutol
embB 4245692 c.-822G>C upstream_gene_variant 0.18 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.18 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.23 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.23 ethambutol
embB 4245726 c.-788_-786delTTGinsCTC upstream_gene_variant 0.21 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.24 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.25 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.3 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.29 ethambutol Uncertain significance
embB 4245807 c.-707_-705delTTAinsCTG upstream_gene_variant 0.32 ethambutol
embA 4245820 p.Ser863Thr missense_variant 0.26 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.27 ethambutol
embB 4247348 p.Thr279Ala missense_variant 0.2 ethambutol
embB 4247355 p.Ala281Val missense_variant 0.22 ethambutol Uncertain significance
embB 4247358 p.Val282Ala missense_variant 0.21 ethambutol Uncertain significance
embB 4247365 c.852A>C synonymous_variant 0.26 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.27 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.27 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.26 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.26 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.34 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.38 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.41 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.42 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.42 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.38 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.36 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.35 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.4 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.31 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.22 ethambutol
embB 4247683 c.1170C>G synonymous_variant 0.21 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.24 ethambutol
embB 4247716 c.1203C>G synonymous_variant 0.23 ethambutol
embB 4247722 c.1209G>C synonymous_variant 0.22 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.21 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.21 ethambutol
embB 4247743 c.1230C>G synonymous_variant 0.25 ethambutol
embB 4247746 c.1233C>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247776 c.1263G>T synonymous_variant 0.25 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.23 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.23 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.28 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.28 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.3 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.31 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.32 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.31 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.32 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.31 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.31 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.3 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.3 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.37 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.42 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.37 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.35 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.34 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.28 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.26 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.24 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.22 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.21 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.2 ethambutol
embB 4248398 c.1885C>T synonymous_variant 0.16 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.17 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.18 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.34 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.3 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.3 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.3 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.35 ethambutol
embB 4249483 c.2970C>G synonymous_variant 0.27 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.26 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.26 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.35 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.24 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4249528 c.3015C>G synonymous_variant 0.26 ethambutol
embB 4249529 p.Ile1006Val missense_variant 0.26 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.26 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.26 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.25 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.2 ethambutol
embB 4249564 c.3051C>T synonymous_variant 0.22 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.23 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.21 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.22 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.83 ethambutol Not assoc w R
aftB 4269183 c.-347T>C upstream_gene_variant 0.23 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.29 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.24 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.24 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.24 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.25 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.25 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.23 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.18 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R