TB-Profiler result

Run: ERR4553705
Summary

Run ID: ERR4553705

Sample name:

Date: 01-04-2023 06:17:57

Number of reads: 2300030

Percentage reads mapped: 99.63

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575479 c.132G>A synonymous_variant 0.99
mshA 576108 p.Ala254Gly missense_variant 0.25
mshA 576482 p.Val379Leu missense_variant 0.15
rpoB 759746 c.-61C>T upstream_gene_variant 0.5
rpoB 761314 p.Phe503Ser missense_variant 0.98
rpoC 762434 c.-936T>G upstream_gene_variant 0.67
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302873 c.-58A>G upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
kasA 2519122 c.1008G>C synonymous_variant 0.94
pepQ 2860159 p.Ala87Gly missense_variant 0.21
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087824 c.1005G>T synonymous_variant 0.91
fbiD 3339734 p.Ala206Gly missense_variant 0.56
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642629 c.1095C>G synonymous_variant 0.99
embC 4242075 p.Arg738Gln missense_variant 0.86
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ethA 4326705 p.Pro257Ser missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0