TB-Profiler result

Run: ERR4799020
Summary

Run ID: ERR4799020

Sample name:

Date: 20-10-2023 03:17:46

Number of reads: 2992379

Percentage reads mapped: 99.62

Strain: lineage4.8;lineage3.1.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 0.38
lineage4 Euro-American LAM;T;S;X;H None 0.62
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.56
lineage3.1 East-African-Indian Non-CAS1-Delhi RD750 0.28
lineage3.1.2 East-African-Indian CAS;CAS2 RD750 0.32
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.48
gyrA 9304 p.Gly668Asp missense_variant 0.49
fgd1 491742 c.960T>C synonymous_variant 0.45
rpoB 759746 c.-61C>T upstream_gene_variant 0.38
rpoC 762434 c.-936T>G upstream_gene_variant 0.4
rpoC 763031 c.-339T>C upstream_gene_variant 0.4
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.37
mmpL5 779352 c.-872C>T upstream_gene_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303928 p.Ala333Val missense_variant 0.23
Rv1258c 1406897 c.444G>A synonymous_variant 0.28
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.49
rrl 1474429 n.772G>A non_coding_transcript_exon_variant 0.54
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.37
PPE35 2167926 p.Leu896Ser missense_variant 0.41
PPE35 2168604 p.Pro670Leu missense_variant 0.36
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 0.38
pncA 2289365 c.-125delC upstream_gene_variant 0.38
ahpC 2726105 c.-88G>A upstream_gene_variant 0.37
ald 3086788 c.-32T>C upstream_gene_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.4
Rv3236c 3613255 c.-139G>A upstream_gene_variant 0.29
embC 4242075 p.Arg738Gln missense_variant 0.44
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246811 p.Gly100Ser missense_variant 0.55
aftB 4267647 p.Asp397Gly missense_variant 0.1
whiB6 4338401 p.Trp41Arg missense_variant 0.54
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.41