TB-Profiler result

Run: ERR4813059
Summary

Run ID: ERR4813059

Sample name:

Date: 01-04-2023 12:30:54

Number of reads: 3150593

Percentage reads mapped: 99.55

Strain: lineage4.3.3

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 0.96
lineage4.3.3 Euro-American (LAM) LAM;T RD115 0.96
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.96 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.96 isoniazid, ethionamide
pncA 2289090 p.His51Arg missense_variant 0.97 pyrazinamide
embB 4247429 p.Met306Leu missense_variant 0.98 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 0.93
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 761032 p.Gln409Arg missense_variant 0.96
rpoC 764995 c.1626C>G synonymous_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304043 p.Trp371Cys missense_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834683 p.Ala381Val missense_variant 0.96
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154817 p.Pro432Leu missense_variant 0.97
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 0.98
thyA 3073868 p.Thr202Ala missense_variant 0.99
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642225 p.Gln231* stop_gained 0.25
clpC1 4038287 c.2418C>T synonymous_variant 0.95
embC 4242182 p.Ala774Ser missense_variant 0.96
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 0.97