TB-Profiler result

Run: ERR4814920

Summary

Run ID: ERR4814920

Sample name:

Date: 01-04-2023 13:33:56

Number of reads: 768175

Percentage reads mapped: 99.47

Strain: lineage3.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3.1 East-African-Indian Non-CAS1-Delhi RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9340 p.Ser680Tyr missense_variant 0.14
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 761114 c.1308G>A synonymous_variant 0.11
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 767293 c.3924C>T synonymous_variant 0.1
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpR5 778451 c.-539C>T upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800934 c.126C>G synonymous_variant 0.13
rplC 801166 p.Gly120Arg missense_variant 0.12
fbiC 1303151 p.Gly74Ala missense_variant 0.25
fbiC 1304278 p.Gly450Cys missense_variant 0.33
embR 1417128 p.Ser74Pro missense_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674961 p.Thr254Ser missense_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170461 p.Gly51Glu missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 0.92
pncA 2289365 c.-125delC upstream_gene_variant 1.0
pncA 2289425 c.-184A>T upstream_gene_variant 0.12
eis 2715432 c.-100C>T upstream_gene_variant 0.15
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ribD 2986864 p.Ala9Gly missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339414 c.297C>T synonymous_variant 0.22
fbiD 3339423 c.306G>A synonymous_variant 0.22
fbiD 3339565 p.Val150Ile missense_variant 0.25
fbiD 3339741 c.624G>T synonymous_variant 0.29
fbiD 3339744 c.627A>C synonymous_variant 0.29
Rv3083 3448570 p.Val23Leu missense_variant 0.15
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641082 c.-453G>A upstream_gene_variant 0.14
alr 3840457 c.964C>T synonymous_variant 0.17
alr 3841489 c.-69T>A upstream_gene_variant 0.12
embC 4240172 p.Val104Met missense_variant 1.0
embC 4241562 p.Arg567His missense_variant 1.0
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4243118 p.Trp1086Gly missense_variant 0.17
embB 4245659 c.-855C>A upstream_gene_variant 0.2
embB 4246603 c.90C>T synonymous_variant 0.29
embB 4248940 c.2427C>T synonymous_variant 0.14
aftB 4267029 p.Asp603Val missense_variant 0.14
aftB 4268630 c.207G>A synonymous_variant 0.22
ubiA 4269331 p.Thr168Ile missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0