TB-Profiler result

Run: ERR4815267
Summary

Run ID: ERR4815267

Sample name:

Date: 01-04-2023 13:46:06

Number of reads: 1033961

Percentage reads mapped: 99.59

Strain: lineage3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5826 p.Glu196Gly missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7618 p.Arg106His missense_variant 0.12
gyrA 9285 p.Ala662Thr missense_variant 0.15
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 760571 c.765G>C synonymous_variant 0.11
rpoB 760633 p.Arg276His missense_variant 0.11
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766582 c.3213C>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781832 c.273T>C synonymous_variant 0.1
fbiC 1303160 p.Gly77Glu missense_variant 0.1
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471683 n.-163C>T upstream_gene_variant 0.12
rrl 1474809 n.1155delG non_coding_transcript_exon_variant 0.67
fabG1 1673380 c.-60C>G upstream_gene_variant 0.1
rpsA 1834920 p.Ala460Glu missense_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102919 c.124C>T synonymous_variant 0.11
katG 2154105 p.Glu669Asp missense_variant 0.12
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2156044 p.Val23Ala missense_variant 0.14
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168487 p.Ile709Asn missense_variant 0.17
PPE35 2169378 p.Phe412Ser missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ahpC 2726514 p.Phe108Leu missense_variant 0.13
Rv2752c 3065649 c.543T>C synonymous_variant 0.15
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474181 p.Lys59Glu missense_variant 1.0
fbiA 3641377 p.Arg279Trp missense_variant 0.1
fbiB 3642075 p.Asp181Asn missense_variant 0.11
alr 3841473 c.-53G>A upstream_gene_variant 1.0
alr 3841612 c.-193_-192insC upstream_gene_variant 0.12
clpC1 4040152 p.Gly185Ser missense_variant 0.15
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ethA 4326226 c.1248C>A synonymous_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0