TB-Profiler result

Run: ERR4816177
Summary

Run ID: ERR4816177

Sample name:

Date: 01-04-2023 14:17:01

Number of reads: 971952

Percentage reads mapped: 71.21

Strain: lineage4.1.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.94 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6895 c.1657delC frameshift_variant 0.1
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9217 p.Asp639Gly missense_variant 0.1
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 764481 p.Lys371Arg missense_variant 0.11
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765432 p.Met688Thr missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776098 p.Thr795Ala missense_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.29
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.33
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.33
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.33
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.45
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.45
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.5
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.4
rrs 1472378 n.533G>T non_coding_transcript_exon_variant 0.33
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.4
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.4
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 0.4
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.33
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.75
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.78
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.78
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.89
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.97
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.93
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.93
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.94
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.94
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.93
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.82
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.98
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.91
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.91
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.81
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.5
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.5
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.4
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.5
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.5
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.5
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.5
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.67
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.63
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.9
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.9
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.93
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.93
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.93
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.92
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.94
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.84
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.67
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.67
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.5
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.45
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.55
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.55
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.5
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.56
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.25
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.25
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.62
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.33
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.36
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.4
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.16
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.17
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.11
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.15
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.19
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.23
rrs 1473150 n.1305T>G non_coding_transcript_exon_variant 0.23
rrs 1473161 n.1316A>C non_coding_transcript_exon_variant 0.33
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.33
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.36
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.33
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.33
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.33
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.36
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.36
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.15
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.23
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.25
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.25
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.25
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.25
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.67
rrl 1474635 n.979_982delACCG non_coding_transcript_exon_variant 0.67
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.29
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.29
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.29
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.17
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.17
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.17
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.17
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.22
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.5
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.4
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.25
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.25
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.22
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.22
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.53
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.59
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.56
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.58
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.43
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
pepQ 2859830 p.Gly197Trp missense_variant 0.12
Rv2752c 3066048 c.144G>A synonymous_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612213 p.Ala302Ser missense_variant 0.1
fbiB 3642831 p.Ser433Thr missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249384 c.2871G>A synonymous_variant 0.11
ethR 4328041 c.496delC frameshift_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0