TB-Profiler result

Run: ERR4816597
Summary

Run ID: ERR4816597

Sample name:

Date: 01-04-2023 14:31:19

Number of reads: 651731

Percentage reads mapped: 99.39

Strain:

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7793 c.492G>A synonymous_variant 0.4
gyrA 8123 p.Leu274Phe missense_variant 0.12
gyrA 8761 p.Val487Glu missense_variant 0.2
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491357 p.Phe192Ser missense_variant 0.17
fgd1 491494 p.Asp238Asn missense_variant 0.29
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576201 p.Arg285His missense_variant 0.2
ccsA 619876 c.-15C>T upstream_gene_variant 0.2
ccsA 620532 c.642T>G synonymous_variant 0.33
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 759967 p.Ser54* stop_gained 0.14
rpoB 761301 c.1497_1498delGG frameshift_variant 0.2
rpoB 761589 c.1786_1791delGCCAAC conservative_inframe_deletion 0.11
rpoB 761673 p.Gly623Trp missense_variant 0.15
rpoB 761682 c.1876C>T synonymous_variant 0.14
rpoB 762072 p.Thr756Ala missense_variant 0.11
rpoB 762376 p.Ala857Val missense_variant 0.14
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766848 p.Gln1160Pro missense_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777054 p.Glu476Gly missense_variant 0.17
mmpL5 777157 c.1324C>A synonymous_variant 0.18
mmpL5 777164 c.1317C>T synonymous_variant 0.18
mmpL5 777588 p.Ala298Glu missense_variant 0.2
mmpL5 777820 c.661C>T synonymous_variant 1.0
mmpL5 778639 c.-159G>A upstream_gene_variant 0.12
mmpR5 779080 p.Ser31Gly missense_variant 1.0
mmpR5 779406 p.Met139Ile missense_variant 0.17
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801438 p.Ser210Arg missense_variant 0.11
fbiC 1303721 p.Gly264Asp missense_variant 0.13
fbiC 1303776 p.Lys282Asn missense_variant 0.14
Rv1258c 1406745 p.Pro199Leu missense_variant 0.2
embR 1416902 p.Val149Gly missense_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471686 n.-160G>T upstream_gene_variant 0.12
fabG1 1673184 c.-256T>A upstream_gene_variant 0.13
fabG1 1673359 c.-81T>C upstream_gene_variant 0.13
fabG1 1673361 c.-79C>G upstream_gene_variant 0.13
fabG1 1673380 c.-60C>G upstream_gene_variant 0.13
tlyA 1918264 p.Val109Leu missense_variant 0.2
tlyA 1918286 p.Gly116Asp missense_variant 0.29
katG 2154711 p.Leu467Phe missense_variant 0.12
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2154758 p.Glu452* stop_gained 0.12
katG 2155196 p.Thr306Ala missense_variant 0.14
katG 2155794 c.318G>A synonymous_variant 0.18
katG 2155909 p.Val68Ala missense_variant 0.18
PPE35 2167745 p.Thr956Arg missense_variant 0.13
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168087 c.2526G>T synonymous_variant 0.18
PPE35 2168853 p.Pro587Leu missense_variant 0.2
PPE35 2169346 p.Asn423Asp missense_variant 0.11
PPE35 2169440 c.1173C>A synonymous_variant 0.13
PPE35 2169538 p.Thr359Ser missense_variant 0.12
PPE35 2169902 p.Leu237Phe missense_variant 0.13
PPE35 2169910 p.Asn235Tyr missense_variant 0.18
PPE35 2170400 c.213G>C synonymous_variant 0.12
PPE35 2170766 c.-154T>C upstream_gene_variant 1.0
Rv1979c 2222771 p.Gln132* stop_gained 0.15
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518331 p.Gly73Cys missense_variant 0.13
kasA 2518879 c.765A>G synonymous_variant 0.12
kasA 2518880 p.Ala256Thr missense_variant 0.12
kasA 2519153 p.Ile347Val missense_variant 0.15
eis 2714239 p.Arg365His missense_variant 0.17
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ahpC 2726341 p.Val50Gly missense_variant 0.33
ahpC 2726669 p.Asp159Glu missense_variant 0.17
folC 2746244 p.Ala452Val missense_variant 0.18
folC 2746324 c.1275C>T synonymous_variant 0.18
folC 2746542 p.Ala353Thr missense_variant 0.14
folC 2746934 p.Arg222Gln missense_variant 0.13
folC 2747455 c.144C>T synonymous_variant 0.18
pepQ 2860399 p.Arg7Gln missense_variant 1.0
thyX 3067597 p.Val117Ile missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087158 c.339G>A synonymous_variant 0.17
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474368 p.Gly121Val missense_variant 0.22
whiB7 3568649 p.Pro11Thr missense_variant 1.0
Rv3236c 3612360 p.Gly253Arg missense_variant 0.14
Rv3236c 3612400 c.717G>A synonymous_variant 0.17
Rv3236c 3612598 c.519G>T synonymous_variant 0.25
fbiB 3641665 p.Asp44Ala missense_variant 0.2
fbiB 3641668 p.Val45Ala missense_variant 0.14
alr 3841473 c.-53G>A upstream_gene_variant 1.0
alr 3841546 c.-126C>A upstream_gene_variant 0.22
clpC1 4039208 c.1497C>A synonymous_variant 0.12
clpC1 4039645 p.His354Asp missense_variant 0.11
clpC1 4040903 c.-199C>T upstream_gene_variant 0.15
embC 4241280 p.Val473Glu missense_variant 0.17
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242651 p.Arg930Leu missense_variant 0.14
embB 4246552 c.40dupC frameshift_variant 0.13
embB 4247830 c.1317A>G synonymous_variant 0.15
embB 4248534 p.Ala674Gly missense_variant 0.1
embB 4249166 p.Gly885Ser missense_variant 0.2
aftB 4267182 p.Gly552Asp missense_variant 0.13
aftB 4267907 c.930C>A synonymous_variant 0.14
aftB 4268707 p.Gly44Ser missense_variant 0.13
aftB 4268742 p.Leu32Arg missense_variant 0.12
ubiA 4269864 c.-32delG upstream_gene_variant 0.29
ethR 4327603 p.Arg19Trp missense_variant 0.22
ethR 4328116 p.Glu190Ile missense_variant 0.12
whiB6 4338420 c.102C>T synonymous_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408076 p.Arg43Gly missense_variant 0.2