TB-Profiler result

Run: ERR4816982
Summary

Run ID: ERR4816982

Sample name:

Date: 01-04-2023 14:44:23

Number of reads: 81682

Percentage reads mapped: 34.45

Strain: lineage4

Drug-resistance: Other

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.78 streptomycin
ethA 4327222 p.Tyr84* stop_gained 1.0 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5923 p.Glu228Asp missense_variant 0.4
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8554 p.Arg418Gln missense_variant 0.4
rpoB 760705 p.Tyr300Cys missense_variant 1.0
rpoB 761051 c.1245G>C synonymous_variant 0.5
rpoB 761054 c.1248G>C synonymous_variant 0.75
rpoB 761057 c.1251G>C synonymous_variant 0.5
rpoB 761060 c.1254C>G synonymous_variant 0.75
rpoB 761084 c.1278C>A synonymous_variant 0.67
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 1.0
rpoB 761096 c.1290G>C synonymous_variant 1.0
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 1.0
rpoB 761102 c.1296A>G synonymous_variant 1.0
rpoC 763053 c.-317T>C upstream_gene_variant 1.0
rpoC 763070 c.-300T>C upstream_gene_variant 1.0
rpoB 763077 p.Val1091Ser missense_variant 1.0
rpoC 763103 c.-267G>C upstream_gene_variant 1.0
rpoC 763461 p.Pro31Leu missense_variant 0.5
rpoC 763528 c.159G>C synonymous_variant 0.67
rpoC 763531 c.162G>C synonymous_variant 0.67
rpoC 763534 c.165T>C synonymous_variant 0.67
rpoC 763537 c.168C>G synonymous_variant 0.67
rpoC 763546 c.177A>G synonymous_variant 0.67
rpoC 763550 p.Tyr61Ala missense_variant 0.67
rpoC 763570 c.201G>C synonymous_variant 1.0
rpoC 763578 p.Phe70Tyr missense_variant 1.0
rpoC 763585 c.216C>G synonymous_variant 1.0
rpoC 763589 p.Ile74Val missense_variant 1.0
rpoC 763606 c.237C>A synonymous_variant 1.0
rpoC 763699 c.330G>T synonymous_variant 1.0
rpoC 763708 c.339G>C synonymous_variant 1.0
rpoC 763714 c.345G>C synonymous_variant 1.0
rpoC 763717 c.348T>C synonymous_variant 1.0
rpoC 763723 c.354G>C synonymous_variant 1.0
rpoC 763724 p.Asp119Asn missense_variant 1.0
rpoC 763729 c.360G>C synonymous_variant 1.0
rpoC 763732 c.363C>G synonymous_variant 1.0
rpoC 763735 c.366G>C synonymous_variant 1.0
rpoC 763751 p.Ile128Val missense_variant 1.0
rpoC 763765 c.396T>G synonymous_variant 1.0
rpoC 763772 p.Val135Met missense_variant 0.67
rpoC 764521 c.1152T>C synonymous_variant 0.25
rpoC 764536 c.1167G>C synonymous_variant 0.29
rpoC 764581 c.1212T>C synonymous_variant 0.4
rpoC 764582 p.Leu405Met missense_variant 0.4
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.75
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 1.0
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.75
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.22
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.25
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.75
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.75
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.2
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.88
rrs 1472247 n.402C>A non_coding_transcript_exon_variant 0.5
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 1.0
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 1.0
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 1.0
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 1.0
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 1.0
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 1.0
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 1.0
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 1.0
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.97
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 1.0
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 1.0
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 1.0
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.22
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 1.0
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 1.0
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.71
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 1.0
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 1.0
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 1.0
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 1.0
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.71
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.12
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.89
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.14
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.86
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.79
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.81
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.79
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.22
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.78
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.8
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.22
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 1.0
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.5
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.5
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.5
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.4
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 1.0
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 1.0
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.5
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.5
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.9
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.4
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.5
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.92
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.75
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.88
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.78
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.4
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.67
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 1.0
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 1.0
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 1.0
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.5
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.58
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.36
rrs 1473161 n.1316A>C non_coding_transcript_exon_variant 0.14
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.42
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.14
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.54
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.36
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.79
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.14
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.13
rrs 1473201 n.1357C>T non_coding_transcript_exon_variant 0.13
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.17
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.73
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.14
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.57
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.5
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.5
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 1.0
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.67
rrs 1473288 n.1443C>G non_coding_transcript_exon_variant 1.0
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 1.0
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.67
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 1.0
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 1.0
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 1.0
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 1.0
rrl 1474200 n.545delT non_coding_transcript_exon_variant 1.0
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0
rrl 1474315 n.658A>G non_coding_transcript_exon_variant 1.0
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 1.0
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 1.0
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 1.0
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 1.0
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 1.0
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.67
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.67
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 1.0
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 1.0
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 1.0
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 1.0
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 1.0
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 1.0
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 1.0
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 1.0
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 1.0
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 1.0
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 1.0
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 1.0
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.8
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.83
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.78
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.78
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.8
rpsA 1833563 p.Ser8Gln missense_variant 0.5
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2987156 c.318G>T synonymous_variant 1.0
thyA 3073893 c.579C>T synonymous_variant 0.25
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
alr 3841545 c.-125G>A upstream_gene_variant 0.5
rpoA 3878496 c.12A>G synonymous_variant 1.0
clpC1 4039694 c.1011G>C synonymous_variant 0.67
clpC1 4039711 c.991_993delTAC conservative_inframe_deletion 0.67
clpC1 4039724 c.981A>G synonymous_variant 0.67
clpC1 4039730 c.975C>G synonymous_variant 0.67
clpC1 4039733 c.972G>C synonymous_variant 0.67
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0