TB-Profiler result

Run: ERR4820367
Summary

Run ID: ERR4820367

Sample name:

Date: 01-04-2023 16:39:05

Number of reads: 8972791

Percentage reads mapped: 99.23

Strain: lineage3.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
lineage3.1 East-African-Indian Non-CAS1-Delhi RD750 1.0
lineage3.1.1 East-African-Indian CAS1-Kili RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.17
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.14
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.14
rrs 1472517 n.672T>C non_coding_transcript_exon_variant 0.15
rrs 1472524 n.679G>A non_coding_transcript_exon_variant 0.14
rrs 1472535 n.690C>T non_coding_transcript_exon_variant 0.11
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.24
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.12
rrs 1472545 n.700A>G non_coding_transcript_exon_variant 0.12
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.25
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.27
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.12
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.23
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.12
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.26
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.1
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.11
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.11
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.11
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.33
rrl 1474581 n.924C>T non_coding_transcript_exon_variant 0.18
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.18
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.33
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.4
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.33
rrl 1474852 n.1195T>C non_coding_transcript_exon_variant 0.33
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170461 p.Gly51Glu missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 0.99
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
embC 4240172 p.Val104Met missense_variant 1.0
embC 4241562 p.Arg567His missense_variant 1.0
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408174 p.Ala10Val missense_variant 1.0