TB-Profiler result

Run: ERR552174
Summary

Run ID: ERR552174

Sample name:

Date: 15-08-2022 10:46:10

Number of reads: 382539

Percentage reads mapped: 99.39

Strain: lineage5.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage5 West-Africa 1 AFRI_2;AFRI_3 RD711 0.99
lineage5.1 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
lineage5.1.1 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrB 6544 p.Ile435Met missense_variant 0.15
gyrB 6670 c.1432delA frameshift_variant 0.14
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9566 c.2265C>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
fgd1 491767 p.Ala329Ser missense_variant 0.13
rpoB 761704 c.1899delC frameshift_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763280 c.-90C>T upstream_gene_variant 1.0
rpoC 765128 p.Tyr587His missense_variant 0.12
rpoC 765161 p.Glu598Lys missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776615 c.1865delC frameshift_variant 0.14
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801109 c.301T>C synonymous_variant 0.11
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
fbiC 1303288 p.Ser120Gly missense_variant 0.18
fbiC 1304723 p.Glu598Gly missense_variant 0.11
Rv1258c 1407273 p.Asp23Val missense_variant 1.0
embR 1417273 c.75C>A synonymous_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1673338 c.-864G>A upstream_gene_variant 1.0
rpsA 1833348 c.-194A>G upstream_gene_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103112 c.-70G>T upstream_gene_variant 1.0
katG 2154347 c.1762_1764delGAG conservative_inframe_deletion 0.14
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290062 c.-821G>A upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2518187 p.Ile25Val missense_variant 0.13
eis 2714329 p.Asp335Gly missense_variant 0.12
ahpC 2725979 c.-214A>G upstream_gene_variant 1.0
folC 2747482 c.117G>T synonymous_variant 0.17
Rv2752c 3066357 c.-166G>T upstream_gene_variant 0.17
ald 3087084 c.266delA frameshift_variant 1.0
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 1.0
Rv3083 3448336 c.-168G>A upstream_gene_variant 1.0
Rv3083 3449644 p.Ala381Thr missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
fprA 3475187 p.Glu394Gly missense_variant 0.15
fprA 3475218 p.Asp404Glu missense_variant 0.15
fbiB 3642437 c.903G>A synonymous_variant 0.12
alr 3840932 c.489C>T synonymous_variant 1.0
ddn 3986987 c.144G>T synonymous_variant 1.0
ddn 3987180 p.Asp113Asn missense_variant 1.0
clpC1 4040409 p.Gly99Asp missense_variant 0.17
embC 4239843 c.-20A>C upstream_gene_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4240913 p.Met351Val missense_variant 0.2
embC 4241138 p.Ala426Pro missense_variant 1.0
embC 4241209 c.1347G>A synonymous_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embA 4245147 p.Pro639Ser missense_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
embB 4249424 p.Leu971Met missense_variant 0.17
aftB 4267746 c.1090delT frameshift_variant 0.17
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethR 4326928 c.-621G>A upstream_gene_variant 1.0
ethA 4327103 p.Gly124Asp missense_variant 1.0
ethA 4327486 c.-13A>G upstream_gene_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0