TB-Profiler result

Run: ERR970454
Summary

Run ID: ERR970454

Sample name:

Date: 02-04-2023 12:02:17

Number of reads: 7993810

Percentage reads mapped: 98.65

Strain: lineage4.1.2

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.99
lineage4.1.2 Euro-American T;H None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.97 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6123 p.Ala295Gly missense_variant 0.98
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764944 p.His525Gln missense_variant 0.97
rpoC 765150 p.Gly594Glu missense_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417140 p.Ala70Ser missense_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.33
rrs 1472754 n.909G>T non_coding_transcript_exon_variant 0.33
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.31
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.29
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.12
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.14
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.16
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.17
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.14
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.14
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.13
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.13
fabG1 1673249 c.-191C>T upstream_gene_variant 0.97
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101847 p.Leu399Pro missense_variant 0.97
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747022 p.Val193Ile missense_variant 0.99
thyA 3073806 c.666C>G synonymous_variant 0.24
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448894 p.Tyr131Asp missense_variant 0.99
Rv3083 3449642 p.Asn380Ser missense_variant 0.99
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
fbiA 3641164 p.Ile208Val missense_variant 0.97
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.99
aftB 4268861 c.-25T>C upstream_gene_variant 0.99
ubiA 4269340 p.Gly165Val missense_variant 0.93
whiB6 4338595 c.-75delG upstream_gene_variant 1.0