TB-Profiler result

Run: SRR6045365
Summary

Run ID: SRR6045365

Sample name:

Date: 04-04-2023 11:58:02

Number of reads: 2231445

Percentage reads mapped: 95.03

Strain: lineage3

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.18 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.21 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7189 p.Ile650Met missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.18
rpoB 759746 c.-61C>T upstream_gene_variant 0.93
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800814 c.6A>G synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.17
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.2
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.12
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.18
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.25
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.29
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.33
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.33
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.42
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.33
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.31
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.22
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.2
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.18
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.22
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.23
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.17
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.23
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.19
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.25
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.19
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.18
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.3
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.2
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.25
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.13
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.12
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.12
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.29
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.5
rrl 1474171 n.514C>T non_coding_transcript_exon_variant 0.44
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.44
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.44
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.44
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.44
rrl 1474199 n.542G>A non_coding_transcript_exon_variant 0.44
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.44
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.33
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.4
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.5
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.5
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.5
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.5
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.5
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.5
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.5
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.6
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.6
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.75
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.75
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.75
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.8
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.8
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.67
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.67
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 1.0
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.67
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 1.0
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.67
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.5
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.5
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.75
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.5
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.75
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.5
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 1.0
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 1.0
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.67
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0
rrl 1474883 n.1226T>C non_coding_transcript_exon_variant 1.0
rrl 1475803 n.2146T>G non_coding_transcript_exon_variant 0.33
rrl 1475894 n.2237C>A non_coding_transcript_exon_variant 0.25
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.11
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.21
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.24
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.19
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.12
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.21
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.21
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.22
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.19
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.33
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.31
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.28
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.26
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.14
fabG1 1674076 p.Thr213Pro missense_variant 0.26
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103225 c.-183A>C upstream_gene_variant 0.23
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.13
PPE35 2170053 p.Thr187Ser missense_variant 0.16
PPE35 2170629 c.-17C>T upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518147 c.33C>T synonymous_variant 0.3
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474494 p.Ala163Val missense_variant 1.0
clpC1 4039667 p.Gln346His missense_variant 1.0
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267812 p.Pro342Leu missense_variant 1.0
aftB 4268545 p.Leu98Phe missense_variant 1.0
ubiA 4269864 c.-31C>G upstream_gene_variant 0.22
ethR 4327768 p.Thr74Ala missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0