Run ID: DRR130118
Sample name:
Date: 31-03-2023 07:05:25
Number of reads: 1904049
Percentage reads mapped: 99.69
Strain: lineage4.9
Drug-resistance: Pre-XDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | T1 | None | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrA | 7570 | p.Ala90Val | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
gyrA | 7572 | p.Ser91Pro | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rpoB | 761110 | p.Asp435Val | missense_variant | 1.0 | rifampicin |
rrs | 1473247 | n.1402C>T | non_coding_transcript_exon_variant | 1.0 | kanamycin, capreomycin, aminoglycosides, amikacin |
katG | 2155169 | p.Ser315Arg | missense_variant | 1.0 | isoniazid |
ahpC | 2726136 | c.-57C>T | upstream_gene_variant | 1.0 | isoniazid |
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol |
embB | 4247574 | p.Asp354Ala | missense_variant | 0.99 | ethambutol |
ethA | 4326994 | c.479delC | frameshift_variant | 1.0 | ethionamide, ethionamide |
pncA | 2287402 | c.414_*1278del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | pyrazinamide |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrB | 6677 | p.Pro480Ser | missense_variant | 1.0 |
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
rpoB | 760574 | c.768G>C | synonymous_variant | 0.99 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1471861 | n.16T>C | non_coding_transcript_exon_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
thyX | 3067959 | c.-14C>G | upstream_gene_variant | 1.0 |
thyA | 3074159 | c.312delA | frameshift_variant | 1.0 |
fbiA | 3640354 | c.-189C>G | upstream_gene_variant | 1.0 |
embC | 4240394 | p.Glu178Lys | missense_variant | 0.98 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4408105 | c.80_97delCGGGACCCGGTGTGGAGC | disruptive_inframe_deletion | 1.0 |