Run ID: ERR1034688
Sample name:
Date: 20-10-2023 21:57:54
Number of reads: 5777182
Percentage reads mapped: 96.94
Strain: lineage4.2.2
Drug-resistance: Pre-XDR-TB
| Drug | Resistance | Supporting mutations |
|---|---|---|
| Rifampicin | R | rpoB p.Gln432Lys (1.00) |
| Isoniazid | R | katG p.Ser315Thr (1.00) |
| Ethambutol | R | embB p.Gly406Asp (1.00) |
| Pyrazinamide | R | pncA c.-11A>G (0.99) |
| Streptomycin | R | gid p.Gln125* (1.00) |
| Fluoroquinolones | R | gyrA p.Asp94Asn (1.00) |
| Moxifloxacin | R | gyrA p.Asp94Asn (1.00) |
| Ofloxacin | R | gyrA p.Asp94Asn (1.00) |
| Levofloxacin | R | gyrA p.Asp94Asn (1.00) |
| Ciprofloxacin | R | gyrA p.Asp94Asn (1.00) |
| Aminoglycosides | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin | ||
| Cycloserine | ||
| Ethionamide | ||
| Clofazimine | ||
| Para-aminosalicylic_acid | ||
| Delamanid | ||
| Bedaquiline | ||
| Linezolid |
| Lineage | Family | Main Spoligotype | RDs | Frequency |
|---|---|---|---|---|
| lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
| lineage4.2 | Euro-American | H;T;LAM | None | 1.0 |
| lineage4.2.2 | Euro-American (Ural) | T;LAM7-TUR | None | 1.0 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
|---|---|---|---|---|---|
| gyrA | 7581 | p.Asp94Asn | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
| rpoB | 761100 | p.Gln432Lys | missense_variant | 1.0 | rifampicin |
| katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
| pncA | 2289252 | c.-11A>G | upstream_gene_variant | 0.99 | pyrazinamide |
| embB | 4247730 | p.Gly406Asp | missense_variant | 1.0 | ethambutol |
| gid | 4407830 | p.Gln125* | stop_gained | 1.0 | streptomycin |
| Gene | Chromosome position | Mutation | Type | Estimated fraction |
|---|---|---|---|---|
| gyrA | 7362 | p.Glu21Gln | missense_variant | 0.99 |
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
| mshA | 576077 | c.730C>T | synonymous_variant | 0.99 |
| rpoC | 762722 | c.-648C>T | upstream_gene_variant | 1.0 |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
| rrl | 1475518 | n.1861A>G | non_coding_transcript_exon_variant | 1.0 |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 0.99 |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
| Rv2752c | 3066280 | c.-89C>T | upstream_gene_variant | 0.99 |
| ald | 3086742 | c.-78A>C | upstream_gene_variant | 1.0 |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
| rpoA | 3877960 | p.Val183Ala | missense_variant | 1.0 |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
| embB | 4248004 | p.Gln497His | missense_variant | 1.0 |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
