TB-Profiler result

Run: ERR11050104
Summary

Run ID: ERR11050104

Sample name:

Date: 02-04-2023 11:58:24

Number of reads: 3481383

Percentage reads mapped: 99.53

Strain: lineage3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9596 c.2295G>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.18
mshA 576113 p.Arg256Gly missense_variant 0.28
mshA 576606 p.Ala420Gly missense_variant 0.41
mshA 576616 c.1269G>C synonymous_variant 0.18
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 761482 p.Ala559Gly missense_variant 0.2
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764181 p.Asp271Gly missense_variant 1.0
rpoC 764367 p.Gly333Ala missense_variant 0.19
rpoC 764534 p.Arg389Gly missense_variant 0.15
rpoC 764537 p.Pro390Ala missense_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.25
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.3
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170769 c.-157C>T upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.2
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
folC 2746528 c.1071C>G synonymous_variant 0.21
pepQ 2860159 p.Ala87Gly missense_variant 0.11
Rv2752c 3064823 p.Val457Leu missense_variant 0.23
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087816 p.Cys333Gly missense_variant 0.19
fbiD 3339734 p.Ala206Gly missense_variant 0.5
fbiD 3339751 p.Ala212Pro missense_variant 0.23
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474213 p.Lys69Asn missense_variant 0.18
rpoA 3878558 c.-51A>T upstream_gene_variant 0.12
rpoA 3878580 c.-73A>C upstream_gene_variant 0.5
rpoA 3878597 c.-90G>C upstream_gene_variant 1.0
rpoA 3878641 c.-134C>G upstream_gene_variant 0.71
embC 4240409 p.Pro183Ala missense_variant 0.38
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.41
embB 4247020 c.507C>G synonymous_variant 0.13
embB 4248328 c.1815G>C synonymous_variant 0.27
whiB6 4338200 p.Asp108His missense_variant 0.33
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408003 p.Asp67Ala missense_variant 1.0