TB-Profiler result

Run: ERR11465954
Summary

Run ID: ERR11465954

Sample name:

Date: 10-01-2024 06:08:56

Number of reads: 2566356

Percentage reads mapped: 99.74

Strain: lineage4.9;lineage4.8.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.99
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.85
lineage4.9 Euro-American (H37Rv-like) T1 None 0.05
lineage4.8.1 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.69
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 0.91
gyrA 7585 p.Ser95Thr missense_variant 0.17
gyrA 9304 p.Gly668Asp missense_variant 0.23
mmpL5 775639 p.Ile948Val missense_variant 0.95
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.98
rrl 1476704 n.3053delC non_coding_transcript_exon_variant 0.81
tlyA 1917972 c.33A>G synonymous_variant 0.91
PPE35 2168149 p.Pro822Ser missense_variant 0.81
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.95
ald 3086788 c.-32T>C upstream_gene_variant 0.16
fbiD 3339040 c.-78T>C upstream_gene_variant 0.62
fbiD 3339113 c.-5A>C upstream_gene_variant 0.61
fbiB 3642874 p.Leu447Arg missense_variant 0.91
alr 3840950 p.Lys157Asn missense_variant 0.16
embC 4242075 p.Arg738Gln missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 0.79
embB 4246544 p.Thr11Pro missense_variant 0.42
embB 4246548 p.Pro12Gln missense_variant 0.26
embB 4246555 c.42G>C synonymous_variant 0.32
embB 4246556 p.Ala15Pro missense_variant 0.32
embB 4246563 p.Leu17Trp missense_variant 0.31
embB 4246567 c.54G>T synonymous_variant 0.32
whiB6 4338595 c.-75delG upstream_gene_variant 0.96